Human Mouse Rat
IHC IP WB
Calcium-activated potassium channel subunit beta-3, Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 3 or BKBeta3a is encoded by the gene KCNMB3. BKbeta3a can bind to KCNMA1 to form a channel in the calcium activated large conductance (MaxiK channel) family. BKbeta3a acts to modulate the calcium sensitivity and gating kinetics of KCNMA1. It is widely expressed in tissues, and is present in several isoforms. Diseases associated with this gene include Familial Febrile Seizures.
Fusion protein amino acids 1-49 (unique N-terminus) of mouse BKBeta3a (accession number Q08460); Human: 86% identity (42/49 amino acids identical); Rat: not in database
No cross-reactivity against BKBeta1, BKBeta2, BKBeta3b or BKBeta4
BKbeta3a K+ channel
TC Supernatant: AB_10673961
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.