Anti-VGlut1 Recombinant Chicken Chimeric mAb FL490 Conjugate (N28/9)

Name: Anti-VGlut1 Recombinant Chicken Chimeric mAb FL490 Conjugate
Brand: Aves Labs
SKU: 78-066-FL490
Price: 549.0 USD
Availability: InStock

Our chicken Anti-VGlut1 recombinant monoclonal antibody is a chimeric antibody derived from NeuroMab clone N28/9. It detects fish, human, mouse, and rat VGlut1, and is purified by affinity chromatography. It is great for use in Flow, IHC, ICC.

Anti-VGlut1 Recombinant Chicken Chimeric mAb FL490 Conjugate

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Applications

Flow, ICC, IHC

Host Species

Chicken

Conjugates and Formulations

Unconjugated

550

594

650

Carrier-Free

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Data Sheet

SKU: 78-066-FL490

Volume: 200 µL

Variant

Price:

$549.00

Quantity:

Ships: 1-5 business days

Product Details

Target

VGlut1

Scientific Background

Vesicular glutamate transporter 1 (Vglut1) is encoded by the gene Slc17a7 and belongs to the vesicular glutamate transporter family. Vglut1 is expressed in glutamatergic neurons in brain regions including the cerebellum, cerebral cortex and hippocampus at synaptic vesicles. Isoform 2 is expressed in retinal. Vglut1 functions to uptake glutamate into synaptic vesicles in excitatory neural cells. Altered expression of Vglut1 has been implicated in several neurological and psychiatric diseases including Alzheimer’s disease, Parkinson’s disease, epilepsy and schizophrenia.

Format

Purified by affinity chromatography

Concentration

0.5 mg/mL

Clonality

Recombinant

Clone

N28/9

Isotype

IgY

Applications

Flow, ICC, IHC

Host Species

Chicken

Gene Name

Slc17a7 Bnpi Vglut1

Molecular Weight

52 kDa

Excitation / Emission

FL490 Ex: 491 nm, Em: 515 nm

Immunogen

Fusion protein amino acids 493-560 (cytoplasmic C-terminus) of rat VGlut1 (accession number Q62634) produced recombinantly in E. Coli

Immunogen Species

Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone N28/9 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone N28/9 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media and conjugated.

Buffer

1X PBS, 0.05% Sodium Azide pH 7.4

Dilution Ranges

IHC: 1:100-1:200
ICC: 1:100-1:200

Conjugate

490

Specificity

Does not cross-react with VGlut2 or VGlut3

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Vesicular glutamate transporter 1 (VGluT1) (Brain-specific Na(+)-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 7)

UniProt ID

Q62634

Shipping

Shipped on ice packs

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Anti-VGlut1 Recombinant Chicken Chimeric mAb FL490 Conjugate (N28/9)

SKU: 78-066-FL490

Product Details

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