Anti-Tyrosine Hydroxylase Antibody (Purified) (LNC1)

Name: Anti-Tyrosine Hydroxylase Antibody (Purified)
Brand: Antibodies Incorporated
SKU: 77-700
Price: 361.0 USD
Availability: InStock

from Antibodies Incorporated Datasheet

Trial Size

98 Citations

Available Conjugates

490

550

594

650

Product Type

Primary Antibody

Species Reactivity

Chicken, Human, Lizard, Mouse, Non-Human Primate, Rat, Vole, Xenopus, Zebrafish

Clone

LNC1

Applications

ICC, IHC, IP, WB

Host Species

Mouse

Format

Purified by Protein A chromatography

Gene Name

TH TYH EC 1.14.16.2

Molecular Weight

59-63 kDa

Go to Full Product Details

Double-labeled fluorescence immunohistochemistry of human midbrain dopamine neurons stained green with LNC1 and red with PitX.

Western Blot of HEK293 cells transfected to express human Tyrosine Hydroxylase isoform 2 and Green Fluorescent Protein demonstrates the specificity of mouse monoclonal antibody LNC1 to tyrosine hydroxylase protein.

LNC1 anti-TH monoclonal antibody was used at 2.5ug/mL to stain endogenous tyrosine hydroxylase in rat brain lysate.

Mouse brain midbrain dopamine neurons in the substantia nigra double-labeled with LNC1 for tyrosine hydroxylase (TH, red and cytoplasmic) and a rabbit antibody to Nuclear Factor Y subunit A (NFYA, green and primarily nuclear).

Double-labeled fluorescence immunohistochemistry of human midbrain dopamine neurons stained green with LNC1 and red with PitX.

Volume: 100 µL

Variant

Price:

$361

Quantity:

Bulk Order Anti-Tyrosine Hydroxylase Antibody (Purified)

Product Details

Target

Tyrosine Hydroxylase (TH)

Target Description

TH is the rate-limiting enzyme in the synthesis of the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine and is responsible for converting L-tyrosine to L-dopa. Synthesis of catecholamines is regulated by the interaction of TH with its’ cofactor, tetrahydrobiopterin (BH4) and the substrates L-tyrosine and molecular oxygen. In humans four TH mRNA splice variants (hTH1-hTH4) have been isolated while subprimate species rely on a single form of TH. It is known that the hTH1-hTH4 variants are identical in their catalytic domain but differ in their N-terminal regulatory domains. Importantly, LNC1 reacts with the catalytic domain of TH and thus with all four isoforms of human TH. The role of TH in the synthesis of catecholamine neurotransmitters suggests a connection between the enzyme and a number of neuropathogenic diseases characterized by irregular catecholamine levels, such as Parkinson's disease, schizophrenia, and dystonia, as well as a variety of cardiovascular diseases.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

LNC1

Isotype

IgG1

Applications

ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

TH TYH EC 1.14.16.2

Molecular Weight

59-63 kDa

Antigen

Tyrosine Hydroxylase purified from PC12 cells

Species Reactivity

Chicken, Human, Lizard, Mouse, Non-Human Primate, Rat, Vole, Xenopus, Zebrafish

Antibody Registry ID

AB_2940724

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

Recognizes an epitope outside of the regulatory N-terminus. Recognizes a protein of approximately 59-61 kDa by Western blot. Does not react with the following on Western Blots: purified dopamine-beta-hydroxylase, phenylalanine hydroxylase, trytophan hydroxylase, dehydropteridine reductase, sepiapterin reductase or phenethanolamine-N-methyl transferase (PNMT). Identifies a single ~60 kDa band on Western Blots of HeLa cells transfected to express human tyrosine hydroxylase.

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe rat brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Tyrosine 3-monooxygenase

UniProt Details

UniProt (Human): P07101
UniProt (Immunogen Species): P07101

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Anti-Tyrosine Hydroxylase Antibody (Purified) (LNC1)

Available Conjugates

Anti-Tyrosine Hydroxylase Antibody (Purified)
SKU: 77-700

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Anti-Tyrosine Hydroxylase Antibody (Purified) (LNC1)

Available Conjugates

Anti-Tyrosine Hydroxylase Antibody (Purified) SKU: 77-700

Bulk Order Anti-Tyrosine Hydroxylase Antibody (Purified)

Product Details

Anti-Tyrosine Hydroxylase Antibody (Purified)
SKU: 77-700