Anti-TRIP8B (Exon 1A/5 Junction) Antibody (N291C/22)

Name: Anti-TRIP8B (Exon 1A/5 Junction) Antibody
Brand: NeuroMab
SKU: 75-334
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet KO Validated

Product Type

Primary Antibody

Species Reactivity

Mouse, Rat

Clone

N291C/22

Applications

ICC, WB

Host Species

Mouse

Format

Purified

Gene Name

Pex5l Pex2 Pex5r Pxr2

Molecular Weight

60 kDa

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Transfected cell immunoblot: extracts of COS cells transiently transfected with carboxy- terminally (C) and amino-terminally (N) GFP- tagged TRIP8b-1a-5, TRIP8b-1a-4 or untagged Kv2.1 plasmid and probed with N291C/22 (left) and N212/7 (right) TC supe.

Immunoblot versus crude membranes from adult rat brain (RBM) and WT and TRIP8b KO mouse brains probed with N291C/22 (left) and N52A/42 (right) TC supe. Mouse brains courtesy of Dane Chetkovich (Northwestern University).

Volume: 100 µL

Variant

Price:

$308

Quantity:

Bulk Order Anti-TRIP8B (Exon 1A/5 Junction) Antibody

Product Details

Target

PEX5-related protein (PEX2-related protein) (PEX5-like protein) (Peroxin-5-related protein) (Tetratricopeptide repeat-containing Rab8b-interacting protein) (Pex5Rp) (TRIP8b)

Target Description

PEX5-related protein, Peroxisomal Biogenesis Factor 5 Like, TPR-containing Rab8b-interacting protein or TRIP8b is encoded by the gene Pex5l. It is a member of the peroxisomal targeting signal receptor family. TRIP8b is a cytoplasmic accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. TRIP8b interacts with the carboxyl-terminal region of HCN channels and regulates their cell-surface expression to the dendrites in many types of neurons. TRIP8b plays a role in regulation of HCN channel cyclic nucleotide kinetics. TRIP8b is expressed in the brain. Diseases associated with PEX5L include Rhizomelic Chondrodysplasia Punctata, Type 5 and Rhizomelic Chondrodysplasia Punctata, Type 2.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N291C/22

Isotype

IgG1

Applications

ICC, WB

Host Species

Mouse

Gene Name

Pex5l Pex2 Pex5r Pxr2

Molecular Weight

60 kDa

Antigen

Synthetic peptide amino acids 1-12 (MYQGHMQLVNEQ, exon 1a (yellow) and exon 5 (green) of constant region) of mouse TRIP8b (also known as TPR-containing Rab8b-interacting protein, Peroxisome biogenesis factor 5-like, Peroxin-5- or PEX5-related/like protein, Pex5Rp, Pex5l, Pex5r, Pex2, Pxr2, accession number Q8C437)

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2315950

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Specific for exon 1a/5 junction (does not react

Quality Control

Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

PEX5-related protein (PEX2-related protein) (PEX5-like protein) (Peroxin-5-related protein) (Tetratricopeptide repeat-containing Rab8b-interacting protein) (Pex5Rp) (TRIP8b)

UniProt Details

UniProt (Human): Q8C437
UniProt (Immunogen Species): Q8C437

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Anti-TRIP8B (Exon 1A/5 Junction) Antibody (N291C/22)

Anti-TRIP8B (Exon 1A/5 Junction) Antibody
SKU: 75-334

Bulk Order Anti-TRIP8B (Exon 1A/5 Junction) Antibody

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Anti-TRIP8B (Exon 1A/5 Junction) Antibody (N291C/22)

Anti-TRIP8B (Exon 1A/5 Junction) Antibody SKU: 75-334

Bulk Order Anti-TRIP8B (Exon 1A/5 Junction) Antibody

Product Details

Anti-TRIP8B (Exon 1A/5 Junction) Antibody
SKU: 75-334