Immunoblot against extracts of COS cells transiently transfected with untagged TRAK1, GFP-tagged TRAK2 or untagged Kv2.1 plasmid probed with N390/43 (left) or N52A/42 (right) TC supe.
Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein)
Trafficking kinesin-binding protein 2 or O-Linked N-Acetylglucosamine Transferase Interacting Protein 98 is encoded by the gene TRAK2. TRAK2 is involved in mitochondrial motility and regulation of endosome-to-lysosome trafficking and preferentially binds dynein. TRAK2 is widely expressed in tissues. Diseases associated with this gene include Juvenile Amyotrophic Lateral Sclerosis and Charcot-Marie-Tooth Disease.
ICC, IHC, WB
TRAK2 ALS2CR3 KIAA0549
Fusion protein amino acids 757-914 (C-terminus) of human TRAK2 (also known as Trafficking kinesin-binding protein 2, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein, GABA-A receptor-interacting factor 1, O-GlcNAc transferase-interacting protein of 98 kDa, EMBL AAH60681.1, Ensembl ENSMUSP00000027186 MGI 1918077, Als2cr3, Grif1, Oip98 and KIAA0549, accession number O60296); Rat: 84% identity (134/159 amino acids identical); Mouse: 84% identity (134/159 amino acids identical); Less than 50% identity with TRAK1
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