Anti-Thyroid Hormone Receptor, ß-Isotype Antibody (2386)

Name: Anti-Thyroid Hormone Receptor, ß-Isotype Antibody
Brand: PhosphoSolutions
SKU: 1240-TRb
Price: 456.0 USD
Availability: InStock

Our Anti-Thyroid Hormone Receptor, ß-Isotype primary antibody from PhosphoSolutions is mouse monoclonal. It detects human Thyroid Hormone Receptor, ß-Isotype and is Protein G purified. It is great for use in WB.

Western blot of hippocampal lysate showing specific immunolabeling of the ~55 kDa TR-β protein.

Click on image to zoom

Species Reactivity

Human

Applications

ELISA, WB

Host Species

Mouse

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Data Sheet

Trial Size

SKU: 1240-TRb

Volume: 100 µL

Variant

Price:

$456.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Thyroid Hormone Receptor, ß-Isotype

Scientific Background

Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRα1, TRα2, TRβ1 and TRβ2. TRα1, TRβ1 and TRβ2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).

Format

Protein G Purified

Clonality

Monoclonal

Clone

2386

Isotype

IgG1

Applications

ELISA, WB

Host Species

Mouse

Gene Name

THRB

Molecular Weight

55 kDa

Immunogen

Synthetic peptide corresponding to amino acid residues from the N-terminal region of human thyroid hormone receptor, β-isotype, conjugated to keyhole limpet hemocyanin (KLH).

Immunogen Species

Human

Species Reactivity

Human

Antibody Registry ID

AB_2492263

Storage

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Physical State

Liquid

Production Notes

Protein G purified culture supernatent.

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Dilution Ranges

WB: 1:1000
WB Brain: 1:1000

Conjugate

Unconjugated

Specificity

Specific for endogenous levels of the ~55 kDa TR-β protein.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Synonyms

Avian erythroblastic leukemia viral (v erb a oncogene homolog 2; Avian erythroblastic leukemia viral; C ERBA 2; v erb a oncogene homolog 2; C ERBA BETA; v erb a oncogene homolog 2 avian; c-erbA-2; erythroblastic leukemia viral; c-erbA-beta; ERBA 2; ERBA BETA; ERBA2; Erythroblastic leukemia viral (v erb a oncogene homolog 2 avian; generalized resistance to thyroid hormone; GRTH; MGC126109; MGC126110; NR1A2; Nuclear receptor subfamily 1 group A member 2; Oncogene ERBA2; PRTH; THB_HUMAN; THR1; THRB 1; THRB 2; thrB; THRB1; THRB2; Thyroid hormone nuclear receptor beta variant 1; Thyroid hormone receptor beta 1; Thyroid hormone receptor beta 2; Thyroid hormone receptor beta; Thyroid hormone receptor beta (erythroblastic leukemia viral (v erb a oncogene homolog 2 avian; Thyroid hormone receptor beta

UniProt ID

P10828
UniProt Summary: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. {ECO:0000269|PubMed:12699376, ECO:0000269|PubMed:14673100, ECO:0000269|PubMed:16781732, ECO:0000269|PubMed:17418816, ECO:0000269|PubMed:18237438, ECO:0000269|PubMed:18798561, ECO:0000269|PubMed:19926848}.

NCBI Gene ID

7068

Shipping

Blue Ice

Western Blot Protocol: Download

General References

Ambrogini, P., Cuppini, R., Ferri, P., Mancini, C., Ciaroni, S., Voci, A., Gerdoni, E. and Gallo, G., 2005. Thyroid hormones affect neurogenesis in the dentate gyrus of adult rat. Neuroendocrinology, 81(4), pp.244-253. PMID: 16113586
Chan, S. and Kilby, M.D., 2000. Thyroid hormone and central nervous system development. The Journal of Endocrinology, 165(1), p.1-8. PMID: 10750030
Constantinou, C., Margarity, M. and Valcana, T., 2005. Region-specific effects of hypothyroidism on the relative expression of thyroid hormone receptors in adult rat brain. Molecular and Cellular Biochemistry, 278(1-2), pp.93-100. PMID: 16180094

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Anti-Thyroid Hormone Receptor, ß-Isotype Antibody (2386)

SKU: 1240-TRb

Product Details

General References

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