Anti-Survival Motor Neuron (SMN) Antibody (4B7)
Our Anti-Survival Motor Neuron (SMN) mouse monoclonal primary antibody from PhosphoSolutions is produced in-house. It detects human, mouse, and rat Survival Motor Neuron (SMN) and is Protein G purified. It is great for use in WB, ICC.
SKU: 1904-SMN
Product Details
Survival Motor Neuron (SMN)
Survival Motor Neuron (SMN) protein, also known as Gemin1, is derived from the SMN gene which has two nearly identical copies located on chromosome 5q13, SMN1 and SMN2 (Lefebvre et al, 1995). SMA, Spinal Muscular Atrophy, is a neurodegenerative disease caused by mutations of the SMN gene that result in a loss of motor neurons and subsequent progressive limb and trunk muscular atrophy and paralysis (Crawford et al, 1996). SMN1 produces functional, full-length SMN protein, while SMN2 encodes a truncated form of SMN protein that is unstable and defective (Wolstencroft et al., 2005). SMN2 plays a key role in the development of SMA in that the number of SMN2 copies modulates disease severity (Monani et al, 2000). The SMN protein is expressed ubiquitously and found in the cytoplasm as well as nuclear Cajal bodies (Young et al, 2000).
Protein G Purified
Monoclonal
4B7
IgG
ICC, WB
Mouse
SMN1
35 kDa
Recombinant human SMN protein.
Human, Mouse, Rat
AB_2801576
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Liquid
Protein G purified tissue culture supernatant.
10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
WB: 1:4000
ICC: 1:50-1:500
ICC: 1:50-1:500
Unconjugated
Specific for endogenous levels of the ~35 kDa survival motor neuron protein.
Western blots performed on each lot.
For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
After date of receipt, stable for at least 1 year at -20°C.
Blue Ice
BCD541 antibody, Component of gems 1 antibody, Gemin 1 antibody, Gemin-1 antibody, OTTHUMP00000125198 antibody, OTTHUMP00000223567 antibody, OTTHUMP00000223568 antibody, OTTHUMP00000224066 antibody, OTTHUMP00000226924 antibody, SMA 1 antibody, SMA 2 antibody, SMA 3 antibody, SMA 4 antibody, SMA antibody, SMA@ antibody, SMA1 antibody, SMA2 antibody, SMA3 antibody, SMA4 antibody, SMN antibody, SMN_HUMAN antibody, SMN1 antibody, SMN2 antibody, SMNT antibody, Survival motor neuron protein antibody, Survival of motor neuron 1 telomeric antibody, T-BCD541 antibody
UniProt (Human): Q16637
UniProt (Immunogen Species): Q16637
UniProt (Immunogen Species): Q16637
6606
Product Specific Protocols
- Western Blot Protocol: Download