Epitope mapped to within amino acids 690-715 (PKLMRHDPLLIPGNDQIDNMDSNVKK, 100% conserved in mouse, rat, human, horse, dog, pig, cow, Rhesus monkey and rabbit, indicated by arrow in image at right) by Daniel Levy (University of Chicago).
Anti-Slo1 Maxi-K+ Channel Antibody
Slo1 maxi-K+ channel
mSlo maxi K+ channel (Calcium-activated potassium channel subunit alpha-1) is a member of BK channel alpha subunit family and has the particularity to be regulated by both Ca2+ and membrane depolarization.BK channels have a tetrameric structure. Each subunit is the product of the KCNMA1 gene. All modulatory subunits encoded by KCNMB1, KCNMB2, KCNMB3, or KCNMB4 can associate with the tetrameric channel. MSlo plays a major role in controlling cell excitability, which regulates smooth muscle contractions, transmitter release, and innate immune system cell activation. MSlo maxi-K+ channel contributes to repolarization of the membrane potential as it exports K+ out of the cytosol.
IHC, IP, WB
Fusion protein amino acids 690-1196 (cytoplasmic C-terminus) of mouse Slo1 (accession number AAA39746); Human: 99% identityRat: 100% identity; Epitope mapped within amino acids 690-715 by Dr. D. Levy (Univ of Chicago); segment is 100% conserved in mouse, rat, human, horse, dog, pig, cow, Rhesus monkey, rabbit.
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
No cross-reactivity reported
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.