Anti-Slo1/BKAlpha Potassium Channel Antibody (L6/48)

Name: Anti-Slo1/BKAlpha Potassium Channel Antibody
Brand: NeuroMab
SKU: 75-421
Price: 329.0 USD
Availability: InStock

2 Citations

Our Anti-Slo1/BKAlpha potassium channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone L6/48. It is KO validated, detects mouse and rat Slo1/BKAlpha potassium channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

Species Reactivity

Mouse, Rat

Applications

ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Carrier-Free

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Data Sheet

KO Validated

SKU: 75-421

Volume: 100 µL

Variant

Price:

$329.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Slo1/BKAlpha potassium channel

Target Description

Calcium-activated potassium channel subunit alpha-1, Potassium Calcium-Activated Channel Subfamily M Alpha 1 or Slo1/BKalpha is encoded by the gene KCNMA1. BKalpha binds to one of 4 different beta subunits to form a channel in the calcium activated large conductance (MaxiK channel) family. This potassium channel is activated by membrane depolarization or an increase in cytosolic ca2+ and mediated the export of K+. BKalpha is involved with various cell processes including contraction of smooth muscle, regulation of transmitter release, innate immunity and regulation of membrane potential. Diseases associated with KCNMA1 include forms of Epilepsy and Developmental Delay Cerebellar Atrophy and Seizures.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

L6/48

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Kcnma1 Kcnma

Molecular Weight

110-130 kDa

Antigen

Fusion protein amino acids 690-1196 (cytoplasmic C-terminus) of mouse Slo1 (accession number Q08460) produced recombinantly in E. Coli

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2493097

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Dilution Ranges

IHC: 1:100

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (mSlo1) (Slowpoke homolog) (Slo homolog) (mSlo)

UniProt ID

Q08460-2

Product Specific References for Applications and Species

Immunohistochemistry: Mouse | Rat
Western Blot: Mouse | Rat

Immunohistochemistry: Mouse
PMID	Dilution	Publication
16903852	not listed	Sailer, C.A., et al. 2006. Immunolocalization of BK channels in hippocampal pyramidal neurons.. European Journal of Neuroscience, 442-54.

Immunohistochemistry: Rat
PMID	Dilution	Publication
25948259	1:100	Hirono, M., et al. 2015. BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells.. Journal of Neuroscience, 7082-7094.

Western Blot: Mouse
PMID	Dilution	Publication
16903852	not listed	Sailer, C.A., et al. 2006. Immunolocalization of BK channels in hippocampal pyramidal neurons.. European Journal of Neuroscience, 442-54.

Western Blot: Rat
PMID	Dilution	Publication
25948259	not listed	Hirono, M., et al. 2015. BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells.. Journal of Neuroscience, 7082-7094.

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Anti-Slo1/BKAlpha Potassium Channel Antibody (L6/48)

SKU: 75-421

Product Details

Product Specific References for Applications and Species

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