Anti-Slo1/BKAlpha Potassium Channel Antibody (L6/23)

Name: Anti-Slo1/BKAlpha Potassium Channel Antibody
Brand: NeuroMab
SKU: 75-408
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet KO Validated

2 Citations

Product Type

Primary Antibody

Species Reactivity

Mouse, Rat

Clone

L6/23

Applications

ICC, IHC, IP, WB

Host Species

Mouse

Format

Purified

Gene Name

Kcnma1 Kcnma

Molecular Weight

110-130 kDa

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Maximum intensity projections of confocal z stacks taken from the apical cochlear region of Eps8−/− (top) and Eps8−/− rescued (bottom) mice using antibodies against BK channels carrying IK,f (red) and the hair-cell marker Myo7a (white). Image from publication CC-BY-4.0. PMID: 36034774

Immunoblot against crude membranes from adult rat brain (RBM), wild-type (MBM-WT) and BKAlpha knockout (MBM- BKaKO) mouse brains probed with L6/23 (left), L6/60 (middle) or N52A/42 (right) TC supe. Reproduced from PLoS One (2010 Wersinger et al, PMID 21079807).

Volume: 100 µL

Variant

Price:

$308

Quantity:

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Product Details

Target

Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (mSlo1) (Slowpoke homolog) (Slo homolog) (mSlo)

Target Description

Calcium-activated potassium channel subunit alpha-1, Potassium Calcium-Activated Channel Subfamily M Alpha 1 or Slo1/BKalpha is encoded by the gene KCNMA1. BKalpha binds to one of 4 different beta subunits to form a channel in the calcium activated large conductance (MaxiK channel) family. This potassium channel is activated by membrane depolarization or an increase in cytosolic ca2+ and mediated the export of K+. BKalpha is involved with various cell processes including contraction of smooth muscle, regulation of transmitter release, innate immunity and regulation of membrane potential. Diseases associated with KCNMA1 include forms of Epilepsy and Developmental Delay Cerebellar Atrophy and Seizures.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

L6/23

Isotype

IgG1

Applications

ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

Kcnma1 Kcnma

Molecular Weight

110-130 kDa

Antigen

Fusion protein amino acids 690-1196 (cytoplasmic C-terminus) of mouse Slo1 (also known as Calcium-activated potassium channel subunit alpha-1, Calcium-activated potassium channel, subfamily M subunit alpha-1, KCa1.1, K(VCA)alpha, BK channel, BKCA alpha, Maxi K channel, Slo-alpha, Slowpoke homolog, Kcnma1 and Kcnma, accession number Q08460); Rat: 99% identity (448/450 amino acids identical); Human: 98% identity (446/454 amino acids identical)

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2491105

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

UniProt Details

UniProt (Human): Q12791
UniProt (Immunogen Species): Q08460-2

Wersinger E, McLean WJ, Fuchs PA, Pyott SJ (2010), 'BK channels mediate cholinergic inhibition of high frequency cochlear hair cells..' PLoS One. 10.1371/journal.pone.0013836.
Zorrilla de San Martín J, Pyott S, Ballestero J, Katz E. (2010), 'Ca(2+) and Ca(2+)-activated K(+) channels that support and modulate transmitter release at the olivocochlear efferent-inner hair cell synapse..' J Neurosci.. 10.1523/JNEUROSCI.2541-10.2010.

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Anti-Slo1/BKAlpha Potassium Channel Antibody (L6/23)

Anti-Slo1/BKAlpha Potassium Channel Antibody
SKU: 75-408

Bulk Order Anti-Slo1/BKAlpha Potassium Channel Antibody

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Anti-Slo1/BKAlpha Potassium Channel Antibody (L6/23)

Anti-Slo1/BKAlpha Potassium Channel Antibody SKU: 75-408

Bulk Order Anti-Slo1/BKAlpha Potassium Channel Antibody

Product Details

Anti-Slo1/BKAlpha Potassium Channel Antibody
SKU: 75-408