Anti-Sequestosome 1 Antibody

Name: Anti-Sequestosome 1 Antibody
Brand: Biosensis
SKU: R-162-100
Price: 327.0 USD
Availability: InStock

Our Anti-Sequestosome 1 rabbit polyclonal primary antibody detects bovine, human, mouse, and rat Sequestosome 1, and is whole serum. It is validated for use in IHC-Frozen.

Species Reactivity

Bovine, Human, Mouse, Rat

Applications

IHC

Host Species

Rabbit

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Data Sheet

SKU: R-162-100

Volume/Size: 100 µL

Variant

Price:

$327.00

Quantity:

Product Details

Target

Sequestosome 1

Scientific Background

Sequestosome 1 is an adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor and interleukin-1. It may regulate signaling cascades through ubiquitination and may also be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. It is present as a homooligomer or heterooligomer and localises to the cytoplasm, late endosome and nucleus. In cardiac muscles it localises to the sarcomeric band. It accumulates in neurofibrillary tangles and in Lewy bodies of neurons from individuals with Alzheimer and Parkinson disease respectively. It is also enriched in Rosenthal fibers of pilocytic astrocytoma and in liver cells it accumulates in Mallory bodies associated with alcoholic hepatitis, Wilson disease, indian childhood cirrhosis and in hyaline bodies associated with hepatocellular carcinoma. Sequestosome 1 is ubiquitously expressed and to date, there are 2 named isoforms produced by alternative splicing. Defects in sequestosome 1 cause sporadic and familial Page disease of bone (PDB). This is a metabolic bone disease characterised by focal areas of increased and disorganised bone turn-over due to activated osteoclasts.

Format

Whole serum

Clonality

Polyclonal

Isotype

Mixed

Applications

IHC

Host Species

Rabbit

Immunogen

Peptide IGAALDTIQYSKH corresponding to the C-terminal part of human Sequestosome 1 (aa: 424-436) conjugated to the Blue Carrier Protein has been used as the immunogen.

Immunogen Species

Human

Species Reactivity

Bovine, Human, Mouse, Rat

Storage

Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Avoid repetitive freeze/thaw cycles. Glycerol (1:1) may be added for an additional stability.

Physical State

Lyophilized

Dilution Ranges

IHC: 1:500-1:5000

Conjugate

Unconjugated

Specificity

The specificity was confirmed by immunohistochemical analysis on paraffin embedded human brain. This antibody is expected to recognize p60 in mouse, rat and bovine.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; ubiquitin-binding protein p62; EBI3-associated protein of 60 kDa; p60; EBIAP; SQSTM1; ORCA; OSIL

UniProt ID

Q13501

Shipping

25°C (ambient)

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Anti-Sequestosome 1 Antibody

SKU: R-162-100

Product Details

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