RGS14 is a member of the RGS family (regulator of G-protein signaling) and is highly expressed in the prefrontal cortex. Hallmark domains of RGS14 include a RGS domain, two Raf-like Ras-binding domains and a GoLoco motif. RGS14 inactivates G protein a subunits. Alterations in this protein have been implicated in Schizophrenia and Alzheimer’s disease.
IHC, ICC, WB
Fusion protein amino acids 1-544 (full-length) of rat RGS14 (also known as Regulator of G-protein signaling 14, RAP1/RAP2-interacting protein and RPIP1, accession number O08773); Mouse: 95% identity (524/547 amino acids identical); Human: 86% identity (475/547 amino acids identical); 45% identity with RGS12 and other RGS proteins; Epitope mapped to within amino acids 444-490 (between 2nd Ras-binding ; GoLoco domains, PDAKTREASSIPPCRSQGCLPRTQTKDSHLPPLSSSLSVEDASGSTG, 2014 Evans et al J Comp Neurol); Mouse: 85% identity (40/47 amino acids identical); Human: 51% identity (24/47 amino acids identical)
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Does not react with RGS12
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.