RGS14 is a member of the RGS family (regulator of G-protein signaling) and is highly expressed in the prefrontal cortex. Hallmark domains of RGS14 include a RGS domain, two Raf-like Ras-binding domains and a GoLoco motif. RGS14 inactivates G protein a subunits. Alterations in this protein have been implicated in Schizophrenia and Alzheimer’s disease.
ICC, IHC, WB
Fusion protein amino acids 1-544 (full-length) of rat RGS14 (also known as Regulator of G-protein signaling 14, RAP1/RAP2-interacting protein and RPIP1, accession number O08773); Mouse: 95% identity (524/547 amino acids identical); Human: 86% identity (475/547 amino acids identical); 45% identity with RGS12 and other RGS proteins; Epitope mapped to within amino acids 444-490 (between 2nd Ras-binding ; GoLoco domains, PDAKTREASSIPPCRSQGCLPRTQTKDSHLPPLSSSLSVEDASGSTG, 2014 Evans et al J Comp Neurol); Mouse: 85% identity (40/47 amino acids identical); Human: 51% identity (24/47 amino acids identical)
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