Anti-Rattin Antibody

Name: Anti-Rattin Antibody
Brand: PhosphoSolutions
SKU: 24359
Price: 456.0 USD
Availability: InStock

Our Rattin rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects rat Rattin and is antigen affinity purified. It is great for use in WB.

Western Blot of 100 ng of Rattin peptide and 50 ug of 293 T cell lysates transfected with plasmids encoding GFP-Rattin showing specific immunolabeling of Rattin.

Click on image to zoom

Species Reactivity

Rat

Applications

ELISA, WB

Host Species

Rabbit

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Data Sheet

SKU: 24359

Title: 100 µL

Variant

Price:

$456.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Rattin

Scientific Background

Rattin, a novel rat gene, encodes a peptide homologous to Humanin, a secreted peptide that specifically protects against neuronal cell death induced by beta-amyloid peptide (Ab) or by mutations causing early-onset familial Alzheimer's disease. Rattin is the prototype of a novel class of peptides, phylogenetically related to Humanin, endowed with protective activity not only against Ab but also toward excitotoxic neuronal death. The rat gene, Rattin, encodes a peptide of 38 residues (15 residues longer than Humanin) showing 73% identity in the conserved region to Humanin.

Format

Antigen Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB

Host Species

Rabbit

Immunogen

Synthetic peptide corresponding to amino acids of the Rattin peptide which are not in the conserved region to Humanin.

Immunogen Species

Rat

Species Reactivity

Rat

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Buffer

PBS + 0.02% NaN3

Dilution Ranges

WB: 1:500-1:1000
WB Brain: 1:500-1:1000

Specificity

Reacts with residues of the Rattin peptide which are not in the conserved region to Humanin.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Synonyms

MOUSE; Humanin-like protein; HNr

UniProt ID

C0HLU6
UniProt Summary: Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by amyloid-beta peptides. Also protects against excitotoxic cell death. Prevents amyloid-beta peptide-induced spatial learning and memory impairments, protects against amyloid-beta peptide-induced suppression of hippocampal long-term potentiation, and inhibits amyloid-beta peptide-induced activation of STAT3 and inhibition of CASP3. Prevents glutamate-induced dendritic atrophy in hippocampal neurons and also prevents glutamate-induced decrease in SYP puncta number and total puncta area. Protects anterior pituitary cells from TNF-induced apoptosis. Plays a role in ovarian follicle development by acting as a cryoprotective factor for granulosa cells in the antral follicle. Increases androgen production in Leydig cells and promotes Leydig cell survival by preventing apoptosis.

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Anti-Rattin Antibody

SKU: 24359

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