Anti-PSD-95 Recombinant Chicken Chimeric mAb FL490 Conjugate (K28/43)

Name: Anti-PSD-95 Recombinant Chicken Chimeric mAb FL490 Conjugate
Brand: Aves Labs
SKU: 78-028-FL490
Price: 549.0 USD
Availability: InStock

Our chicken Anti-PSD 95 recombinant monoclonal antibody is a chimeric antibody derived from NeuroMab clone K28/43. It is KO validated, detects chicken, human, mouse, non-human primate, and rat PSD 95, and is purified by affinity chromatography. It is great for use in IHC, ICC.

Anti-PSD-95 Recombinant Chicken Chimeric mAb FL490 Conjugate

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Applications

ICC, IHC

Host Species

Chicken

Conjugates and Formulations

Unconjugated

550

594

650

Carrier-Free

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Data Sheet

KO Validated

SKU: 78-028-FL490

Volume: 200 µL

Variant

Price:

$549.00

Quantity:

Ships: 1-5 business days

Product Details

Target

PSD 95

Scientific Background

PSD-95 is a member of the MAGUK (membrane associated guanylate kinase) family (which also includes PSD-93, SAP97 and SAP102) and functions as a scaffold protein that can cluster membrane receptors, ion channels, including NMDA receptor subunits, Kv1 potassium channels and Caspr2. The protein is encoded by DLG4, contains hallmark PDZ, SH3 and GuK domains and is found at post synaptic densities where it plays an important role in the formation and maintenance of synaptic junctions (Zhou and Blumberg, 2003). Indeed, overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. Antibodies against PSD95/DLG4 are frequently used in conjunction with pre-synaptic markers to localize synapses by microscopy

Format

Purified by affinity chromatography

Concentration

0.5 mg/mL

Clonality

Recombinant

Clone

K28/43

Isotype

IgY

Applications

ICC, IHC

Host Species

Chicken

Gene Name

DLG4 PSD95

Molecular Weight

95-110 kDa (varies with cell background due to phosphorylation)

Excitation / Emission

FL490 Ex: 491 nm, Em: 515 nm

Immunogen

Fusion protein amino acids 77-299 (PDZ domains 1 and 2) of human PSD-95 (accession number P78352) produced recombinantly in E. Coli

Immunogen Species

Human

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone K28/43 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone K28/43 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media and conjugated.

Buffer

1X PBS, 0.05% Sodium Azide pH 7.4

Dilution Ranges

IHC: 1:500
ICC: 1:500

Conjugate

490

Specificity

No cross-reactivity against recombinant Chapsyn-110, SAP97 or SAP102

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)

UniProt ID

P78352

Shipping

Shipped on ice packs

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Anti-PSD-95 Recombinant Chicken Chimeric mAb FL490 Conjugate (K28/43)

SKU: 78-028-FL490

Product Details

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