Anti-PEBP (phosphatidylethanolamie binding protein) Antibody

Name: Anti-PEBP (phosphatidylethanolamie binding protein) Antibody
Brand: PhosphoSolutions
SKU: 1600-PEBP
Price: 394.0 USD
Availability: InStock

Our Anti-PEBP (phosphatidylethanolamie binding protein) primary antibody from PhosphoSolutions is rabbit polyclonal. It detects rat PEBP (phosphatidylethanolamie binding protein) and is neat serum. It is great for use in WB.

Western blot of rat brain lysate showing the specific immunolabeling of the ~22 kDa PEBP protein.

Click on image to zoom

Species Reactivity

Rat

Applications

ELISA, WB

Host Species

Rabbit

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Data Sheet

Trial Size

SKU: 1600-PEBP

Volume: 100 µL

Variant

Price:

$394.00

Quantity:

Ships: 1-2 business days

Product Details

Target

PEBP (phosphatidylethanolamie binding protein)

Scientific Background

Phosphatidylethanolamine binding protein (PEBP), also known as Raf kinase inhibitory protein (RKIP) is a highly conserved multifunctional protein that modulates the Raf/MAPK signaling cascade and has been implicated as a suppressor of metastatic cancer (Trakul N et al., 2005). PEBP has been shown to not only inhibit cell proliferation but also to induce differentiation of human keratinocytes (Yamazaki et al., 2004). Dysregulation of calpain activity results in cellular degeneration in conditions such as Alzheimer’s disease and recently PEBP has been identified as a potential in vivo calpain substrate (Chen at al., 2006).

Format

Neat Serum

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB

Host Species

Rabbit

Gene Name

PEBP1

Molecular Weight

22 kDa

Immunogen

Purified native rat PEBP

Immunogen Species

Rat

Species Reactivity

Rat

Antibody Registry ID

AB_2492204

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Production Notes

Neat serum

Buffer

Neat serum

Dilution Ranges

WB: 1:1000
WB Brain: 1:1000

Conjugate

Unconjugated

Specificity

Specific for endogenous levels of the ~22 kDa PEBP protein.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Synonyms

Epididymis luminal protein 210; Epididymis secretory protein Li 34; Epididymis secretory protein Li 96; HCNP; HCNPpp; HEL 210; HEL S 34; HEL S 96; Hippocampal cholinergic neurostimulating peptide; Neuropolypeptide h3; PBP; PEBP; PEBP 1; PEBP-1; Pebp1; PEBP1_HUMAN; Phosphatidylethanolamine binding protein; Phosphatidylethanolamine binding protein 1; Prostatic binding protein; Prostatic-binding protein; R kip; Raf kinase inhibitor protein; Raf kinase inhibitory protein; RKIP

UniProt ID

P31044
UniProt Summary: Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. {ECO:0000250, ECO:0000269|PubMed:18294816}.; HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity). {ECO:0000250}.

NCBI Gene ID

29542

Shipping

Blue Ice

Western Blot Protocol: Download

General References

Trakul, N., Menard, R.E., Schade, G.R., Qian, Z. and Rosner, M.R., 2005. Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation. Journal of Biological Chemistry, 280(26), pp.24931-24940. PMID: 15886202
Yamazaki, T., Nakano, H., Hayakari, M., Tanaka, M., Mayama, J. and Tsuchida, S., 2004. Differentiation induction of human keratinocytes by phosphatidylethanolamine-binding protein. Journal of Biological Chemistry, 279(31), pp.32191-32195. PMID: 15155742
Chen, Q., Wang, S., Thompson, S.N., Hall, E.D. and Guttmann, R.P., 2006. Identification and characterization of PEBP as a calpain substrate. Journal of Neurochemistry, 99(4), pp.1133-1141. PMID: 17018026

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Anti-PEBP (phosphatidylethanolamie binding protein) Antibody

SKU: 1600-PEBP

Product Details

General References

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