Anti-Parkin Antibody
Our Parkin rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human Parkin and is antigen affinity purified. It is great for use in WB.
SKU: 24552
Product Details
Parkin
Parkinson's disease is a common neurodegenerative disease with complex clinical features. Mutations in the gene, Parkin (PARK2), appear to be responsible for the pathogenesis of autosomal recessive juvenile Parkinsonism. Parkin plays a role in the ubiquitin-mediated proteolytic pathway by removal and/or detoxification of abnormally folded or damaged protein. Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of Parkin. Parkin may protect neurons against alpha synuclein toxicity, proteasomal dysfunction, gpr37 accumulation, and kainate-induced excitotoxicity. It may play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. Parkin also regulates cyclin e during neuronal apoptosis and may represent a tumor suppressor gene.
Antigen Affinity Purified
Polyclonal
IgG
WB
Rabbit
PRKN
Synthetic peptide corresponding to amino acids from the N-terminal region of human Parkin protein.
Human
Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.
Liquid
PBS + 0.02% NaN3
WB: 1:500-1:1000
WB Brain: 1:500-1:1000
WB Brain: 1:500-1:1000
Reacts with the N-terminal region of the 52 kDa human Parkin protein.
Western blots performed on each lot.
For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
United States
After date of receipt, stable for at least 1 year at -20°C.
Blue Ice
PRKN, E3 ubiquitin-protein ligase parkin, PARK2
UniProt (Human): O60260
UniProt (Immunogen Species): O60260
UniProt (Immunogen Species): O60260