Our Anti-Park7 (DJ-1) primary antibody from PhosphoSolutions is mouse monoclonal. It detects bovine, human, mouse, and rat Park7 (DJ-1) and is Protein G purified. It is great for use in WB, IHC, ICC.
Western blot of rat kidney lysate showing specific immunolabeling of the ~21 kDa Park7 protein.
Park7, also known as DJ-1, is a member of the peptidase C56 family of proteins and is thought to function as a molecular chaperone. Mutations in park7 have been associated with autosomal recessive, early onset Parkinson’s disease (Bonifati et al., 2003). Recently, park7 has been shown to inhibit microtubule associated protein 1B aggregation thus leading to neuronal apoptosis (Wang et al., 2011).
Protein G purified culture supernatant
Monoclonal
4H4
IgG1
ICC, IHC, WB
Mouse
PARK7
21 kDa
Full length recombinant human Park7 expressed in and purified from E. coli.
Bovine, Human, Mouse, Rat
AB_2492201
Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.
Liquid
Protein G purified culture supernatant.
PBS + 10 mM NaN3.
WB: 1:2000
IHC: 1:5000
ICC: 1:1000-1:5000
Unconjugated
Specific for endogenous levels of the ~21 kDa Park7 protein.
Western blots performed on each lot.
For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
After date of receipt, stable for at least 1 year at -20°C.
Blue Ice
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Bonifati V, Rizzu P, van Baren MJ, Schaap O, Breedveld GJ , Krieger E, Dekker MC, Squitieri F, Ibanez P, Joosse M, van Dongen JW, Vanacore N, van Swieten JC, Brice A, Meco G, van Duijn CM, Oostra BA, Heutink P. (2003) Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science. Jan 10;299(5604):256-9. PMID: 12446870
Wang Z, Zhang Y, Zhang S, Guo Q, Tan Y, Wang X, Xiong R, Ding J, Chen S. (2011) DJ-1 can inhibit microtubule associated protein 1 B formed aggregates. Mol Neurodegener. Jun 6;6:38. PMID: 21645326
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