Pannexin 2 is encoded by the gene PANX2. PANX2 is a member of the pannexin family. PANX2 combines with pannexin 1 to form cell type-specific gap junctions with distinct properties. PANX2 is expressed in the eye, thyroid, prostate, kidney, liver, and central nervous system. Diseases associated with PANX2 include Oculodentodigital Dysplasia and Chronic Closed-Angle Glaucoma.
Fusion protein amino acids 11-664 (all but first 10 amino acids, encompassing extracellular and cytoplasmic domains) of rat Pannexin-2 (also known as Panx2 and Px2, accession number P60571); Mouse: 98% identity (645/657 amino acids identical); Human: 91% identity (564/615 amino acids identical); Less than 30% identity with Pannexin-1 and Pannexin-3
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Does not cross-react with Pannexin-1 or Pannexin-3
Each new lot of this antibody is tested to confirm that it shows the expected immunoperoxidase-diaminobenzidine / immunofluorescence staining pattern when used to stain brain sections.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.