The ß subunits of voltage-gated potassium channels are members of the potassium channel, voltage-gated, shaker-related subfamily. Kvßs are cytoplasmic subunits that modulate the characteristics of the membrane spanning, channel-forming alpha-subunits. Beta subunits can promote the closure of channels or enhance channel activity depending on other channel proteins. There are three ß subunits (Kvß1, Kvß2, Kvß3) which are coded by three different genes. Additionally, there is alternative splicing of these three genes, further diversifying the functions and tissue expression of the family.
IHC, ICC, WB
Kcnab1 Kvb1 Kcnab3 Ckbeta3 Kcnab2 Ckbeta2 Kcnb3
Synthetic peptide amino acids 350-367 (EIDSILGNKPYSKKDYRS, C-terminus) of human Kvbeta2 (also known as Voltage-gated potassium channel subunit beta-2, K(+) channel subunit beta-2, Neuroimmune protein F5, KCNAB2, KCNA2B, KCNK2, Ckbeta2, I2rf5 and Kcnb3, accession number Q13303); Mouse: 100% identity (18/18 amino acids identical); Rat: 100% identity (18/18 amino acids identical) 75% identity with Kvbeta1 and Kvbeta3
Human, Mouse, Rat
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Reacts with Kvbeta1
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.