Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] and probed with K40/17 (left) or N52A/42 (right) TC supe.
Anti-Pan-Kvbeta K+ Channel Antibody
Pan-Kvbeta K+ channel
The ß subunits of voltage-gated potassium channels are members of the potassium channel, voltage-gated, shaker-related subfamily. Kvßs are cytoplasmic subunits that modulate the characteristics of the membrane spanning, channel-forming alpha-subunits. Beta subunits can promote the closure of channels or enhance channel activity depending on other channel proteins. There are three ß subunits (Kvß1, Kvß2, Kvß3) which are coded by three different genes. Additionally, there is alternative splicing of these three genes, further diversifying the functions and tissue expression of the family.
Kcnab1 Kvb1 Kcnab3 Ckbeta3 Kcnab2 Ckbeta2 Kcnb3
Fusion protein amino acids 1-401 (full-length) of rat Kv1 (also known as voltage-gated potassium channel subunit beta-1, accession number P63144); Mouse: 100% identity (401/401 amino acids identical); Human: 100% identity (401/401 amino acids identical)
Greater than 80% identity with Kv2
Greater than 60% identity with Kv3
Human, Mouse, Rat
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.