Immunostaining of spinal cord samples from WT and Gamma-protocadherin KO mice with N159/5 TC supe. Data courtesy of Joshua Weiner, University of Iowa.
Gamma-protocadherins belong to a superfamily of homophilic cell-adhesion proteins. These cell adhesion proteins are thought to be involved in establishing and function of cell-cell connections in brain. These proteins are widely expressed in the nervous system and brain.
Fusion protein corresponding to amino acids 808-931 (C-terminal cytoplasmic constant domain) of mouse Gamma-protocadherin-A1 that is shared by all 22 Gamma-protocadherins (A subfamily amino acids ~807-930, B subfamily amino acids ~789-912 and C subfamily amino acids ~818-941); Human: 99% identity (123/124 amino acids identical)
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