This antibody recognizes an epitope that is shared by all 22 Gamma-protocadherins (Cross-reacts with all Gammaprotocadherin-A proteins, but not B or C and recognizes endogenous levels of PCDHGs by western blot, immunoprecipitation, and immunocytochemistry).
Immunoblot versus brain samples from WT and Gamma- protocadherin KO mice. Data courtesy of Joshua Weiner, University of Iowa.
Cadherins are calcium-dependent cell-cell adhesion molecules, and protocadherins constitute a subfamily of non-classic cadherins. Members of the protocadherin gamma subfamily are encoded by 22 tandemly arranged genes within the PCDHG gene cluster on chromosome 5q31. The 22 PCDHG genes function as 'variable' exons that are individually spliced to a downstream constant region to form distinct PCDHG transcripts. The variable PCDHG exons encode the extracellular and transmembrane domains of the protocadherin protein, and the common region encodes the intracellular domain. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain.
Fusion protein corresponding to amino acids 720-804 (variable cytoplasmic domain) of mouse Gamma-protocadherin-A3 (also known as PCDH-gamma-A3, accession number Q91XY5); Human: 80% identity (68/84 amino acids identical); Greater than 75% identity with other Gamma-protocadherin-A proteins
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Cross-reacts with all Gamma protocadherin-A, -B and -C proteins
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
24 months from opening
Protocadherin gamma A3 (Protocadherin gamma subfamily A, 3)
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