Anti-Orexin-A Antibody

Name: Anti-Orexin-A Antibody
Brand: Biosensis
SKU: R-104-100
Price: 327.0 USD
Availability: InStock

Our Anti-Orexin-A rabbit polyclonal primary antibody detects bovine, and rat Orexin-A, and is whole serum. It is validated for use in IHC-Frozen.

Immunohistochemical staining of orexin A in rat zona incerta neurons using Rabbit antibody to Orexin A (14-33): whole serum, catalogue number R-104-100, at a dilution of 1 in 1000.

Orexin A-immunoreactive cell bodies and fibers were visualized in floated cryostat sections of the rat lateral hypothalamus. The R-104-100 antibody (1:50 000) was detected with the biotinylated secondary antibody-ABC method and nickel-diaminobenzidine chromogen. Photo courtesy of Dr. Erik Hrabovszky, Hungarian Academy of Sciences, Budapest, Hungary.

Immunohistochemical staining of orexin A in rat zona incerta neurons using Rabbit antibody to Orexin A (14-33): whole serum, catalogue number R-104-100, at a dilution of 1 in 1000.

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Species Reactivity

Bovine, Rat

Applications

IHC

Host Species

Rabbit

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Data Sheet

SKU: R-104-100

Volume/Size: 100 µL

Variant

Price:

$327.00

Quantity:

Product Details

Target

Orexin-A

Scientific Background

FUNCTION: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. SUBCELLULAR LOCATION: Endoplasmic reticulum; rough endoplasmic reticulum. Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses. SIMILARITY: Belongs to the orexin family.

Format

Whole serum

Clonality

Polyclonal

Isotype

Mixed

Applications

IHC

Host Species

Rabbit

Immunogen

A synthetic peptide (CRLYELLHGAGNHAAGILTL) as part of Bovine Orexin A (aa: 14-33) conjugated to KLH has been used as the immunogen.

Immunogen Species

Bovine

Species Reactivity

Bovine, Rat

Storage

Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Physical State

Lyophilized

Dilution Ranges

IHC: 1:1000-1:2000

Application Details

This is an antiserum for immunohistochemistry on Orexin A containing neurons exhibiting intense labelling of neurons with very low back ground.

Conjugate

Unconjugated

Specificity

The specificity for this antiserum has been confirmed by immunohistochemistry on rat brain and the results reflect the current literature. This antibody is known to react with rat Orexin A.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

Orexin-A; Hypocretin-1; Hcrt1

UniProt ID

P56717

Shipping

25°C (ambient)

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Anti-Orexin-A Antibody

SKU: R-104-100

Product Details

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