Anti-NGFR/p75 neurotrophin receptor (p75NTR) Antibody (Saporin) (MC192)

Name: Anti-NGFR/p75 neurotrophin receptor (p75NTR) Antibody (Saporin)
Brand: Biosensis
SKU: M-1755-100-IT
Price: 1047.0 USD
Availability: InStock

Our Anti-NGFR/p75 neurotrophin receptor (p75NTR) mouse monoclonal primary antibody detects rat NGFR/p75 neurotrophin receptor (p75NTR), and is purified. It is validated for use in-vivo.

Immunohistochemical staining of p75NTR in rat forebrain. (A) Brain section from a control rat. (B) Brain section from a rat injected intraventricularly with 4 µg of 192-Saporin. Seven days after the treatment the rat was perfused with 4% paraformaldehyde and free floating section at 40 µm was used for staining.

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Species Reactivity

Rat

Host Species

Mouse

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Data Sheet

SKU: M-1755-100-IT

Volume/Size: 100 µg

Variant

Price:

$1,047.00

Quantity:

Product Details

Target

NGFR/p75 neurotrophin receptor (p75NTR)

Format

Purified

Clonality

Monoclonal

Clone

MC192

Isotype

IgG1

Host Species

Mouse

Immunogen

Rat NGF receptor (p75NTR)

Immunogen Species

Rat

Species Reactivity

Rat

Storage

Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water to achieve a conjugate concentration of 1 mg/mL. Centrifuge to remove any insoluble material. Final buffer contains no preservatives.Lyophilized product is shipped at ambient room temperature. Upon receipt, pulse-centrifuge the vial to collect solid that may be entrapped in the lid. After reconstitution, immediately prepare aliquots and keep the undiluted stock at -80°C for long-term storage. Avoid repeated thaw-freezing. For short-term storage, keep at 2-8°C for up to 2 weeks. it is recommended to handle this product under sterile conditions.

Physical State

Lyophilized

Production Notes

Conjugate was purified by ion-exchange chromatography. Purity > 90% by non-reducing SDS-PAGE

Buffer

Lyophilized from a 1 mg/mL solution containing PBS pH 7.2-7.6 without preservative.

Application Details

1. To specifically target and eliminate rat cells expressing p75NTR in vivo. MC192-saporin has been used to selectively lesion cholinergic neurons of basal forebrain to create an animal model to study Alzheimer's disease.
2. To be used as a model for gene delivery into neurons.

Conjugate

Unconjugated

Specificity

MC192 antibody is specific only for rat NGFR, no reactivity to human or mouse NGFR has been reported This monoclonal antibody does not cross react with p75NTR-expressing cells in other species than rat.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

Low-affinity nerve growth factor receptor; NGF receptor; Gp80-LNGFR; p75 ICD; Low affinity neurotrophin receptor p75NTR; CD271

UniProt ID

P07174; P20656

Shipping

25°C (ambient)

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Anti-NGFR/p75 neurotrophin receptor (p75NTR) Antibody (Saporin) (MC192)

SKU: M-1755-100-IT

Product Details

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