Anti-Neurturin (NTN) Antibody

Name: Anti-Neurturin (NTN) Antibody
Brand: Biosensis
SKU: R-1561-100
Price: 337.0 USD
Availability: InStock

Our Anti-Neurturin (NTN) rabbit polyclonal primary antibody detects human, mouse, and rat Neurturin (NTN), and is whole serum. It is validated for use in IHC-Frozen.

IHC staining of Rabbit antibody to Neurturin (R-1561-100) in rat dorsal root ganglia (at 1:1,000).

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Species Reactivity

Human, Mouse, Rat

Applications

IHC

Host Species

Rabbit

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Data Sheet

SKU: R-1561-100

Volume/Size: 100 µL

Variant

Price:

$337.00

Quantity:

Product Details

Target

Neurturin (NTN)

Scientific Background

Neurturin (NTN) is a member of the GDNF family of neurotrophic factors. This protein is a potent survival factor for several populations of central and peripheral neurons in mature and developing rodents. FUNCTION: Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells. SUBUNIT: Homodimer; disulfide-linked. SUBCELLULAR LOCATION: Secreted protein. DISEASE: Defects in NRTN are a cause of Hirschsprung disease (HSCR). In association with mutations of RET gene, and possibly with other loci, defects in NRTN are involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.

Format

Whole serum

Clonality

Polyclonal

Isotype

Mixed

Applications

IHC

Host Species

Rabbit

Immunogen

Recombinant human Neurturin (rh NTN)

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Storage

Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Physical State

Lyophilized

Dilution Ranges

WB: 1:2000

Conjugate

Unconjugated

Specificity

Specificity of this product was demonstrated by immunohistochemistry and dot blot showed no cross reactivity with GDNF. This antibody is known to react with human, mouse and rat.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

NRTN; NTN;

UniProt ID

Q99748

Shipping

25°C (ambient)

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Anti-Neurturin (NTN) Antibody

SKU: R-1561-100

Product Details

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