Anti-Neurturin (NTN) Antibody (1B11)
Our Anti-Neurturin mouse monoclonal primary antibody detects human Neurturin, and is IgG. It is validated for use in WB.
Western-Blot detection of human NRTN expressed in CHO cells. Line 1. hNRTN-containing CHOEBNALT85 cell culture supernatant. Line 2. Negative control - CHOEBNALT85 cell culture supernatant. 5 µl of supernatant were loaded per line. Primary antibody dilution 1:5000 was used. Antibody recognizes protein dimeric, and monomeric variants.
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SKU: M-1670-100
Product Details
Neurturin
Neurturin (NTN) is a member of the GDNF family of neurotrophic factors. This protein is a potent survival factor for several populations of central and peripheral neurons in mature and developing rodents. FUNCTION: Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells. SUBUNIT: Homodimer; disulfide-linked. SUBCELLULAR LOCATION: Secreted protein. DISEASE: Defects in NRTN are a cause of Hirschsprung disease (HSCR). In association with mutations of RET gene, and possibly with other loci, defects in NRTN are involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.
IgG
Monoclonal
1B11
IgG1
WB
Mouse
Recombinant human NRTN protein produced using CHO-based suspension cell line. Protein was purified from the cell culture supernatant.
Human
Human
Store at -20°C or -70°C upon receipt. After opening divide antibody into smaller aliquots and store at -20°C or -70°C for up to six months. Avoid multiple freeze-thaw cycles as product degradation may result.
Liquid
Protein G purified IgG
PBS pH 7.4, with 0.1% sodium azide
WB: 1:5000-1:10000
Unconjugated
Human NTN (Neurturin).
For research use only.
United States
12 months after date of receipt (unopened vial).
25°C (ambient)

