Array tomography immunofluorescence of Lowicryl-embedded sections from adult mouse cortex layer 2/3 with L115/13 (green), GABA (red) and DAPI (blue). Volume reconstruction of 35 serial 70 nm sections show two NPY-positive neurons with varying levels of GABA reactivity, as well as some NPY-reactive axonal varicosities. Images courtesy of Kristina Micheva (Stanford).
Anti-Neuropeptide Y Antibody
Bulk Order Anti-Neuropeptide Y Antibody
Pro-neuropeptide Y [Cleaved into: Neuropeptide Y (Neuropeptide tyrosine) (NPY); C-flanking peptide of NPY (CPON)]
Neuropeptide Y is encoded by the gene NPY. NPY is a member of the NPY family. NPY is a neuropeptide that influences many physiological processes including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. NPY functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. NPY is widely expressed in the central nervous system. Diseases associated with NPY include Eating Disorder and Adjustment Disorder.
AT, ICC, IHC
Fusion protein amino acids 28-97 (all but signal peptide) of human NPY (also known as Neuropeptide Y, Neuropeptide tyrosine, C-flanking peptide of NPY and CPON, accession number P01303); Rat: 96% identity (67/70 amino acids identical); Mouse: 94% identity (66/70 amino acids identical); ~50% identity with Peptide YY
Human, Mouse, Rat
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.