Anti-Neurexin-1-Beta (Staining) Antibody (N170A/1)

Name: Anti-Neurexin-1-Beta (Staining) Antibody
Brand: NeuroMab
SKU: 75-216
Price: 361.0 USD
Availability: InStock

from NeuroMab Datasheet

3 Citations

Product Type

Primary Antibody

Species Reactivity

Human, Mouse

Clone

N170A/1

Applications

ICC, WB

Host Species

Mouse

Format

Purified by Protein A chromatography

Gene Name

NRXN1

Molecular Weight

50 kDa

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Transfected cell immunoblot: extracts of COS cells transiently transfected with Flag-tagged Neurexin-1-Alpha, Neurexin-1- Beta or untagged Kv2.1 plasmid and probed with N170A/1 TC supe (left) and rabbit anti-Flag (right).

Volume: 100 µL

Variant

Price:

$361

Quantity:

Bulk Order Anti-Neurexin-1-Beta (Staining) Antibody

Product Details

Target

Neurexin-1-Beta (staining)

Target Description

Neurexin-1Beta is a member of the neurexin family. Neurexin-1Beta is a membrane bound receptor and binds neuroligins and forms complexes at neuronal synapses in the central nervous system. Binding parterns for Neurexin 1beta include CASK, Neuroligins 1-3 and DAG1. Neurexin-1Beta serves as a presynaptic marker and plays an important role in assembling presynaptic and postsynaptic machinery. This protein may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins and possibly plays a role in synaptic junctions formation or maintenance.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N170A/1

Isotype

IgG1

Applications

ICC, WB

Host Species

Mouse

Gene Name

NRXN1

Molecular Weight

50 kDa

Antigen

Synthetic peptide amino acids 47-64 (ASSLGAHHIHHFHGSSKH, extracellular N-terminus) of rat Neurexin-1-Beta (accession number Q63373)

Species Reactivity

Human, Mouse

Antibody Registry ID

AB_2155531

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

Does not cross-react with Neurexin-2-Beta

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Neurexin-1-beta (Neurexin I-beta)

UniProt Details

UniProt (Human): Q9ULB1
UniProt (Immunogen Species): P58400

Yamagata M, Duan X, Sanes JR. (2018), 'Cadherins Interact With Synaptic Organizers to Promote Synaptic Differentiation..' Frontiers in Molecular Neuroscience. 10.3389/fnmol.2018.00142.
Futai K, Doty CD, Baek B, Ryu J, Sheng M. (2013), 'Specific trans-synaptic interaction with inhibitory interneuronal neurexin underlies differential ability of neuroligins to induce functional inhibitory synapses..' Journal of Neuroscience. 10.1523/JNEUROSCI.1811-12.2013.
Yamagata M, Sanes JR. (2012), 'Transgenic strategy for identifying synaptic connections in mice by fluorescence complementation (GRASP)..' Frontiers in Molecular Neuroscience. 10.3389/fnmol.2012.00018.

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Anti-Neurexin-1-Beta (Staining) Antibody (N170A/1)

Anti-Neurexin-1-Beta (Staining) Antibody
SKU: 75-216

Bulk Order Anti-Neurexin-1-Beta (Staining) Antibody

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Anti-Neurexin-1-Beta (Staining) Antibody (N170A/1)

Anti-Neurexin-1-Beta (Staining) Antibody SKU: 75-216

Bulk Order Anti-Neurexin-1-Beta (Staining) Antibody

Product Details

Anti-Neurexin-1-Beta (Staining) Antibody
SKU: 75-216