Anti-Nerve growth factor (Beta-NGF) Antibody

Name: Anti-Nerve growth factor (Beta-NGF) Antibody
Brand: Biosensis
SKU: C-1558-500
Price: 347.0 USD
Availability: InStock

Our Anti-Nerve growth factor (Beta-NGF) chicken polyclonal primary antibody detects human, mouse, and rat Nerve growth factor (Beta-NGF), and is affinity-purified. It is validated for use in ELISA, IHC-Frozen, WB.

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Species Reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host Species

Chicken

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Data Sheet

SKU: C-1558-500

Volume/Size: 500 µL

Variant

Price:

$347.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Nerve growth factor (Beta-NGF)

Scientific Background

FUNCTION: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons. SUBUNIT: Homodimer, associated by noncovalent forces. SUBCELLULAR LOCATION: Secreted protein. SIMILARITY: Belongs to the NGF-beta family.

Format

Affinity-purified

Clonality

Polyclonal

Isotype

IgY

Applications

ELISA, IHC, WB

Host Species

Chicken

Immunogen

Mixture of two mouse beta NGF peptides (74-85 and 113-124 aa).

Immunogen Species

Mouse

Species Reactivity

Human, Mouse, Rat

Storage

Short term storage at 2-8°C for one week. At -20°C as an undiluted liquid for up to 12 months.

Physical State

Liquid

Buffer

PBS with 0.02% sodium azide.

Dilution Ranges

WB: 1:500-1:2000
IHC: 1:50-1:1000

Conjugate

Unconjugated

Specificity

Human beta NGF, cross reactivity to other species NGF is expected.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

beta-nerve growth factor; Beta-NGF; nerve growth factor (beta polypeptide; NGF; nerve growth factor; NGFB; beta subunit

UniProt ID

P01138
UniProt Summary: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (Probable). The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI. Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form.

NCBI Gene ID

4803

Shipping

2-8°C (on cold packs)

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Anti-Nerve growth factor (Beta-NGF) Antibody

SKU: C-1558-500

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