Anti-NCKX4 Antibody (N414/25)

Name: Anti-NCKX4 Antibody
Brand: NeuroMab
SKU: 75-404
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet KO Validated

2 Citations

Product Type

Primary Antibody

Species Reactivity

Human, Rat

Clone

N414/25

Applications

ICC, IHC, WB

Host Species

Mouse

Format

Purified

Gene Name

SLC24A4 NCKX4

Molecular Weight

60 kDa

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Immunoblot against membranes from wild- type (N4+/+) or NKCX4 knockout (N4-/-) mouse brains probed with N414/25 TC supe. Data courtesy of Sunita Sharma and Jonathan Lytton (University of Calgary).

Adult rat hippocampus immunohistochemistry.

Immunoblot against extracts of COS cells transiently transfected with Flag- tagged NCKX2, NCKX3 or NCKX4 plasmid and probed with N414/25 (left) or N52A/42 (right) TC supe.

Immunoblot against membranes from wild- type (N4+/+) or NKCX4 knockout (N4-/-) mouse brains probed with N414/25 TC supe. Data courtesy of Sunita Sharma and Jonathan Lytton (University of Calgary).

Volume: 100 µL

Variant

Price:

$308

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Product Details

Target

Sodium/potassium/calcium exchanger 4 (Na(+)/K(+)/Ca(2+)-exchange protein 4) (Solute carrier family 24 member 4)

Target Description

Sodium/potassium/calcium exchanger 4, Na(+)/K(+)/Ca(2+)-Exchange Protein 4 or NCKX4 is encoded by the gene SLC24A4. NCKX4 is a member of the potassium-dependent sodium/calcium exchanger protein family. NCKX4 is thought to play roles in olfactory function and in tooth enamel formation. It is expressed in the aorta, lung, thymus and brain, particularly enriched in neurons. Diseases associated with SLC24A4 include cause amelogenesis imperfecta.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N414/25

Isotype

IgG2b

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

SLC24A4 NCKX4

Molecular Weight

60 kDa

Antigen

Fusion protein amino acids 246-424 (third intracellular loop) of human NCKX4 isoform 3 (also known as Sodium/potassium/calcium exchanger 4, Na(+)/K(+)/Ca(2+)- exchange protein 4, Solute carrier family 24 member 4 and SLC24A4, accession number Q8NFF2-3); Human: 90% identity with isoform 1 (179/198 amino acids identical); Mouse: 89% identity with isoform 2 and 81% identity with isoform 1 (161/179 and 161/198 amino acids identical); Rat: 81% identity (161/198 amino acids identical); 40% identity with NCKX3 and other NCKX proteins

Species Reactivity

Human, Rat

Antibody Registry ID

AB_2491110

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Does not cross-react with NCKX2 or NCKX3

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Sodium/potassium/calcium exchanger 4 (Na(+)/K(+)/Ca(2+)-exchange protein 4) (Solute carrier family 24 member 4)

UniProt Details

UniProt (Human): Q8NFF2
UniProt (Immunogen Species): Q8NFF2-3

Vinberg F, Wang T, De Maria A, Zhao H, Bassnett S, Chen J, Kefalov VJ. (2017), 'The Na+/Ca2+, K+ exchanger NCKX4 is required for efficient cone-mediated vision..' Elife.. 10.7554/eLife.24550.
Bronckers AL, Jalali R, Lytton J. (2017), 'Reduced Protein Expression of the Na+/Ca2++K+-Exchanger (SLC24A4) in Apical Plasma Membranes of Maturation Ameloblasts of Fluorotic Mice..' Calcif Tissue Int.. 10.1007/s00223-016-0197-4.

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Anti-NCKX4 Antibody (N414/25)

Anti-NCKX4 Antibody
SKU: 75-404

Bulk Order Anti-NCKX4 Antibody

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Anti-NCKX4 Antibody (N414/25)

Anti-NCKX4 Antibody SKU: 75-404

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Product Details

Anti-NCKX4 Antibody
SKU: 75-404