Sodium channel subunit beta-2 or Navbeta2 Na+ channel is encoded by SCN2B. Voltage gated sodium channels are made up of an alpha (pore forming) subunit and 1 or 2 beta subunits. Navß2 is a transmembrane protein and acts as a regulatory subunit in excitable membranes and modulates the kinetics of channel. Nabß2 is expressed in many tissues, including the central and peripheral nervous system, heart, and skeletal muscle. Diseases associated with this gene include Familial Atrial Fibrillation
ICC, IHC, WB
Fusion protein amino acids 1-215 (full-length) of mouse Navbeta2 (also known as Sodium channel subunit beta-2, Scn2b, UNQ326/PRO386 and Gm183, accession number Q56A07); Rat: 97% identity (209/215 amino acids identical); Human: 92% identity (198/215 amino acids identical); 30% identity with Navbeta1, Navbeta3 or Navbeta4
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Does not cross-react with Navbeta1, Navbeta3 or Navbeta4 (based on KO validation results)
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.