Anti-Navbeta2 Na+ Channel Antibody (N395/68)

Name: Anti-Navbeta2 Na+ Channel Antibody
Brand: NeuroMab
SKU: 75-379
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet KO Validated

3 Citations

Product Type

Primary Antibody

Species Reactivity

Mouse, Rat

Clone

N395/68

Applications

ICC, IHC, WB

Host Species

Mouse

Format

Purified

Gene Name

Scn2b Gm183

Molecular Weight

40 kDa

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Immunoblot against crude membranes from adult rat brain (RBM) and wild-type (WT) and Navbeta2 knockout (KO) mouse brains probed with N395/68 (left) and N52A/42 (right) TC supe. Mouse brains courtesy of Lori Isom (University of Michigan).

Adult rat hippocampus immunohistochemistry.

Volume: 100 µL

Variant

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Product Details

Target

Sodium channel subunit beta-2

Target Description

Sodium channel subunit beta-2 or Navbeta2 Na+ channel is encoded by SCN2B. Voltage gated sodium channels are made up of an alpha (pore forming) subunit and 1 or 2 beta subunits. Navß2 is a transmembrane protein and acts as a regulatory subunit in excitable membranes and modulates the kinetics of channel. Nabß2 is expressed in many tissues, including the central and peripheral nervous system, heart, and skeletal muscle. Diseases associated with this gene include Familial Atrial Fibrillation

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N395/68

Isotype

IgG2b

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Scn2b Gm183

Molecular Weight

40 kDa

Antigen

Fusion protein amino acids 1-215 (full-length) of mouse Navbeta2 (also known as Sodium channel subunit beta-2, Scn2b, UNQ326/PRO386 and Gm183, accession number Q56A07); Rat: 97% identity (209/215 amino acids identical); Human: 92% identity (198/215 amino acids identical); 30% identity with Navbeta1, Navbeta3 or Navbeta4

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2315896

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Does not cross-react with Navbeta1, Navbeta3 or Navbeta4 (based on KO validation results)

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Sodium channel subunit beta-2

UniProt Details

UniProt (Human): O60939
UniProt (Immunogen Species): Q56A07

Browne L, Smith KE, Jagger DJ. (2017), 'Identification of Persistent and Resurgent Sodium Currents in Spiral Ganglion Neurons Cultured from the Mouse Cochlea..' eNeuro. 10.1523/ENEURO.0303-17.2017.
Ji X, Saha S, Gao G, Lasek AW, Homanics GE, Guildford M, Tapper AR, Martin GE. (2017), 'The Sodium Channel β4 Auxiliary Subunit Selectively Controls Long-Term Depression in Core Nucleus Accumbens Medium Spiny Neurons..' Frontiers in Neuroscience. 10.3389/fncel.2017.00017.
Buffington SA, Rasband MN. (2013), 'Na+ channel-dependent recruitment of Navβ4 to axon initial segments and nodes of Ranvier..' Journal of Neuroscience. 10.1523/JNEUROSCI.4051-12.2013.

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Anti-Navbeta2 Na+ Channel Antibody (N395/68)

Anti-Navbeta2 Na+ Channel Antibody
SKU: 75-379

Bulk Order Anti-Navbeta2 Na+ Channel Antibody

Product Details

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Anti-Navbeta2 Na+ Channel Antibody (N395/68)

Anti-Navbeta2 Na+ Channel Antibody SKU: 75-379

Bulk Order Anti-Navbeta2 Na+ Channel Antibody

Product Details

Anti-Navbeta2 Na+ Channel Antibody
SKU: 75-379