Werner syndrome ATP-dependent helicase, WRN RecQ Like Helicase or DNA Helicase, RecQ-Like Type 3 is encoded by the gene WRN and is a member of the WRN RecQ Like Helicase family. WRN acts as a DNA helicase that is involved in DNA repair, replication, recombination and maintenance of DNA stability. WRN is a multifunctional enzyme with ATP dependent helicase activity, and is the only RecQ helicase member that has 3’ to 5’ exonuclease activity. WRN is expressed within the central nervous system and brain Diseases associated with this gene include Werner Syndrome and Medulloblastoma.
Purified
1 mg/mL
Monoclonal
N405/74
IgG2a
ICC, IHC
Mouse
Scn1b
24 kDa
Fusion protein amino acids 14-160 (extracellular N-terminus) of rat Navbeta1 (also known as Sodium channel subunit beta-1 and Scn1b, accession number Q00954); Mouse: 99% identity (146/147 amino acids identical); Human: 97% identity (143/147 amino acids identical); 50% identity with Navbeta2 or Navbeta3
Mouse, Rat
AB_2637012
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
