Mitofusin 2, or transmembrane GTPase Mfn2 (MFN2) is a mitochondrial membrane protein with GTPase activity that functions to aid mitochondrial clustering and fusion. It may also play a role in mitochondrial metabolism. It is expressed in the outer membrane of mitochondria. MFN2 is expressed in many tissues including the heart, skeletal muscle, tongue, and brain. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI,
Purified
1 mg/mL
Monoclonal
N153/5
IgG2a
ICC, IHC, WB
Mouse
Mfn2 Kiaa0214 Marf
90 kDa
Fusion protein amino acids 370-600 (cytoplasmic N-terminus) of mouse Mitofusin-2 (also known as Transmembrane GTPase Mfn2, Hypertension-related protein 1, Mitochondrial assembly
regulatory factor, Mitochondrial transmembrane GTPase FZO1A and Protein HSG, accession number Q80U63); Rat: 97% identity (226/231 amino acids identical); Human: 92% identity (214/231 amino acids identical); ~55% identity with Mitofusin-1
Mouse, Rat
AB_2297598
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
