Anti-Mitofusin-2 Antibody (N153/5)

Name: Anti-Mitofusin-2 Antibody
Brand: NeuroMab
SKU: 75-173
Price: 295.0 USD
Availability: InStock

from NeuroMab Datasheet KO Validated

1 Citation

Product Type

Primary Antibody

Species Reactivity

Mouse, Rat

Clone

N153/5

Applications

ICC, IHC, WB

Host Species

Mouse

Format

Purified

Gene Name

Mfn2 Kiaa0214 Marf

Molecular Weight

90 kDa

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Immunoblot versus crude cardiac mitochondrial preps from WT, Mfn1 KO or Mfn2 KO mice and probed with N153/5 TC supe (top) and Porin antibody (bottom). Data courtesy of Dr. Suzanne Hoppins, Dr. Laura Lackner and Dr. Jodi Nunnari, UCDavis.

Adult rat hippocampus immunohistochemistry.

Volume: 100 µL

Variant

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Product Details

Target

Mitofusin-2

Target Description

Mitofusin 2, or transmembrane GTPase Mfn2 (MFN2) is a mitochondrial membrane protein with GTPase activity that functions to aid mitochondrial clustering and fusion. It may also play a role in mitochondrial metabolism. It is expressed in the outer membrane of mitochondria. MFN2 is expressed in many tissues including the heart, skeletal muscle, tongue, and brain. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI,

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N153/5

Isotype

IgG2a

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Mfn2 Kiaa0214 Marf

Molecular Weight

90 kDa

Antigen

Fusion protein amino acids 370-600 (cytoplasmic N-terminus) of mouse Mitofusin-2 (also known as Transmembrane GTPase Mfn2, Hypertension-related protein 1, Mitochondrial assembly regulatory factor, Mitochondrial transmembrane GTPase FZO1A and Protein HSG, accession number Q80U63); Rat: 97% identity (226/231 amino acids identical); Human: 92% identity (214/231 amino acids identical); ~55% identity with Mitofusin-1

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2297598

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

No cross-reactivity against Mitofusin-1

Quality Control

Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Mitofusin-2 (EC 3.6.5.-) (Hypertension-related protein 1) (Mitochondrial assembly regulatory factor) (HSG protein) (Transmembrane GTPase MFN2)

UniProt Details

UniProt (Human): O95140
UniProt (Immunogen Species): Q80U63

Hoppins S, Edlich F, Cleland MM, Banerjee S, McCaffery JM, Youle RJ, Nunnari J. (2011), 'The soluble form of Bax regulates mitochondrial fusion via MFN2 homotypic complexes..' Molecular Cell. 10.1016/j.molcel.2010.11.030.

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Anti-Mitofusin-2 Antibody (N153/5)

Anti-Mitofusin-2 Antibody
SKU: 75-173

Bulk Order Anti-Mitofusin-2 Antibody

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Anti-Mitofusin-2 Antibody (N153/5)

Anti-Mitofusin-2 Antibody SKU: 75-173

Bulk Order Anti-Mitofusin-2 Antibody

Product Details

Anti-Mitofusin-2 Antibody
SKU: 75-173