Anti-MCT1 Antibody

Name: Anti-MCT1 Antibody
Brand: PhosphoSolutions
SKU: 24124
Price: 456.0 USD
Availability: InStock

Our MCT1 rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human MCT1 and is antigen affinity purified. It is great for use in WB.

Western Blot of transfected HEK 293T cell lysate showing specific immunolabeling of MCT1.

Click on image to zoom

Species Reactivity

Human

Applications

ELISA, WB

Host Species

Rabbit

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Data Sheet

SKU: 24124

Title: 100 µL

Variant

Price:

$456.00

Quantity:

Ships: 1-2 business days

Product Details

Target

MCT1

Scientific Background

MCT-1 is a novel gene that was identified from T-cell leukemia/lymphoma cell lines with limited homology to a region of Cyclin H. MCT-1 is a novel candidate oncogene that results in a shortened G1 phase and increased rate of proliferation.

Format

Antigen Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB

Host Species

Rabbit

Gene Name

SLC16A1

Immunogen

Synthetic peptide corresponding to amino acids from the N-terminal region of human MCT1 protein

Immunogen Species

Human

Species Reactivity

Human

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Buffer

PBS + 0.02% NaN3

Dilution Ranges

WB: 1:500-1:1000
WB Brain: 1:500-1:1000

Specificity

Reacts with the N-terminal region of human MCT1

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Synonyms

HHF7; Monocarboxylate transporter 1; MCT1; MCT1D; MCT 1; Slc16a1; Monocarboxylic acid transporter 1; Solute carrier family 16 member 1

UniProt ID

P53985
UniProt Summary: Bidirectional proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH. The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate. MCT1 is a major lactate exporter. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis. Facilitates the protonated monocarboxylate form of succinate export, that its transient protonation upon muscle cell acidification in exercising muscle and ischemic heart. Functions via alternate outward- and inward-open conformation states. Protonation and deprotonation of 309-Asp is essential for the conformational transition.

NCBI Gene ID

6566

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Blue Ice

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Anti-MCT1 Antibody

SKU: 24124

Product Details

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