Anti-Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) Antibody

Name: Anti-Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) Antibody
Brand: Biosensis
SKU: S-070-100
Price: 327.0 USD
Availability: InStock

Our Anti-Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) sheep polyclonal primary antibody detects human Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2), and is whole serum. It is validated for use in IHC-Frozen.

Species Reactivity

Human

Applications

IHC

Host Species

Sheep

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Data Sheet

SKU: S-070-100

Volume/Size: 100 µL

Variant

Price:

$327.00

Quantity:

Product Details

Target

Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)

Scientific Background

LRRK2 is a member of the leucine-rich repeat kinase family. It role is yet unknown but it may play a role in the phoshorylation of proteins central to parkinson diseases. LRRK2 contains an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a mLK-like domain and a WD40 domain. LRRK2 is present in the cytoplasm but also associates with the mitochondrial outer membrane. Defects in LRRK2 are the cause of Parkinson disease 8 (PARK8). Parkinson disease is characterised by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK8 is an autosomal-dominant late-onset parkinsonism, characterized by onset from 50 to 65 years, with slow progression and relatively benign course.

Format

Whole serum

Clonality

Polyclonal

Isotype

Mixed

Applications

IHC

Host Species

Sheep

Immunogen

A synthetic peptide (LKRKRKILSSDDSLRSS; aa 946-962) as part of human LRRK2 protein conjugated to the Blue Carrier Protein has been used as the immunogen.

Immunogen Species

Human

Species Reactivity

Human

Storage

Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent.

Physical State

Lyophilized

Dilution Ranges

IHC: 1:500-1:10000

Conjugate

Unconjugated

Specificity

Specificity for LRRK2 has been confirmed by IHC. This antiserum has been successfully tested in human. Other species have not yet been tested.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

Leucine-rich repeat serine/threonine-protein kinase 2; Dardarin; LRRK2; PARK8

UniProt ID

Q5S007

Shipping

25°C (ambient)

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Anti-Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) Antibody

SKU: S-070-100

Product Details

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