Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and COS-1 cells transiently transfected with KCNQ1, KCNQ2, KCNQ3, KCNQ4, KCNQ5 or Kv2.1 plasmids and probed with pure N26A/23.
Anti-Kv7.2/KCNQ2 K+ Channel Antibody
Kv7.2/KCNQ2 K+ channel
Potassium voltage-gated channel subfamily Q member 2 is encoded by the gene KCNQ2. KCNQ2 is a member of the potassium channel family, KQT (TC 1.A.1.15) subfamily, Kv7.2/KCNQ2 sub-subfamily. KCNQ2 associates with KCNQ3 to form a potassium channel with nearly identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness of synaptic inputs. KCNQ2 is expressed in the brain and spinal cord. Diseases associated with KCNQ2 include Epileptic Encephalopathy, Early Infantile, 7 and Seizures, Benign Familial Neonatal 1.
Fusion protein amino acids 1-59 (cytoplasmic N-terminus) of human KCNQ2 (also known as Potassium voltage-gated channel subfamily KQT member 2 or KvLQT2, Kv7.2 and KQT-like 2, accession number O43526); Rat: 96% identity (56/58 amino acids identical); Mouse: 96% identity (56/58 amino acids identical)
Human, Mouse, Rat
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
No cross-reactivity reported
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.