Electron micrograph shows K75/41 immunolabelling in the hippocampus using a pre-embedding immunogold method. Immunogold particles (arrows) were observed along the extrasynaptic plasma membrane of dendritic shafts (Den) of interneurons establishing synaptic contacts with excitatory axon terminals (b). Scale bar = 500 nm. Courtesy Dr. Rafael Lujan (Universidad de Castilla-La Mancha).
Anti-Kv4.3 K+ Channel Antibody
Kv4.3 K+ channel
Kv4.3 K+ channel (Potassium voltage-gated channel subfamily D member 3 ) is a member of the mammalian Shal-related family and the potassium voltage gated channel subunit family. Kv4 subunit family includes four Kv4 a subunits (Kv4.1, Kv4.2 and Kv4.3). However only Kv4.2 and Kv4.3 are predominantely epressed in the brain (Alfaro-Ruiz et al., 2005). KV4.3 subunit is encoded by gene KCND3 in human. It has been demonstrated that Kv 4.2 and Kv4.3 are often colocalized with pain-modulating molecules in rat spinal lamina II excitatory interneurons (Huang et al., 2005).
IHC, IP, WB
75 kDa in rat brain membrane preparations
Fusion protein amino acids 415-636 (cytoplasmic C- terminus) of rat Kv4.3 (accession number Q62897); Human: 99% identity (203/205 amino acids); Mouse: 98% identity (201/205 amino acids)
Human, Mouse, Rat
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
No cross-reactivity against rat Kv4.2 expressed in transfected cells.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
24 months from opening
Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3)