Anti-Kv3.2 Potassium Channel Antibody (N410/17)

Name: Anti-Kv3.2 Potassium Channel Antibody
Brand: NeuroMab
SKU: 75-397
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet KO Validated

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

N410/17

Applications

ICC, IHC, WB

Host Species

Mouse

Format

Purified

Gene Name

Kcnc2

Molecular Weight

80-100 kDa (varies due to post-translational modifications)

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Adult rat hippocampus immunohistochemistry.

Immunoblot against crude membranes from adult rat brain (RBM), mouse brain (MBM) and wild-type (WT) and Kv3.2 knockout (KO) mouse brains probed with N410/17 (left) and N52A/42 (right) TC supe. Mouse brains courtesy of Bernardo Rudy (NYU School of Medicine).

Whole brain immunohistochemistry.

Volume: 100 µL

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Product Details

Target

Potassium voltage-gated channel subfamily C member 2 (Potassium channel voltage-gated Shaw-related subfamily C member 2) (Shaw-like potassium channel) (Voltage-gated potassium channel subunit Kv3.2)

Target Description

Potassium voltage-gated channel subfamily C member 2 or Kv3.2 potassium channel, is a member of the potassium channel, voltage-gated, shaker-related subfamily and the Shaw subfamily (the family includes 4 members Kv3.1-Kv3.4). Kv3.2 is primarily expressed in brain and found in the cortex and hippocampus. It has also been detected in the thalamus and caudate nucleus. Kv3.2 is a membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Diseases associated with KCNC2 include Spinocerebellar Ataxia 13 and Episodic Ataxia, Type 2

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N410/17

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Kcnc2

Molecular Weight

80-100 kDa (varies due to post-translational modifications)

Antigen

Fusion protein amino acids 474-613 (cytoplasmic C-terminus) of rat Kv3.2a (also known as Potassium voltage-gated channel subfamily C member 2, Kcnc2 and KSHIIIA, accession number P22462-3); Human: 97% identity (137/140 amino acids identical); Mouse: 86% identity (120/140 amino acids identical); 50% identity with Kv3.1

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2491084

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate. Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Potassium voltage-gated channel subfamily C member 2 (Potassium channel voltage-gated Shaw-related subfamily C member 2) (Shaw-like potassium channel) (Voltage-gated potassium channel subunit Kv3.2)

UniProt Details

UniProt (Human): Q96PR1
UniProt (Immunogen Species): P22462-3

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Anti-Kv3.2 Potassium Channel Antibody (N410/17)

Anti-Kv3.2 Potassium Channel Antibody
SKU: 75-397

Bulk Order Anti-Kv3.2 Potassium Channel Antibody

Product Details

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Anti-Kv3.2 Potassium Channel Antibody (N410/17)

Anti-Kv3.2 Potassium Channel Antibody SKU: 75-397

Bulk Order Anti-Kv3.2 Potassium Channel Antibody

Product Details

Anti-Kv3.2 Potassium Channel Antibody
SKU: 75-397