Anti-Kv1.1 K+ Channel (External) Antibody (K36/15)
Primary Antibody
Mouse, Rat
K36/15
ICC, IHC, WB
Mouse
Purified by Protein A chromatography
Kcna1
56 kDa (could be 65-85 kDa depending on glycosylation)
![Immunoblot versus crude brain membranes from adult mouse (MBM), rat (RBM) and human cerebral cortex [HBM(Cx)] and hippocampus [HBM(H)] probed with K36/15 (left) or N52A/42 (right) TC supe.](http://www.antibodiesinc.com/cdn/shop/products/validation-image-73-105-k36-15-wb-1_45d4f2d0-b0bc-43a6-8dc1-834ffee2fd56_{width}x.jpg?v=1626902754)
Immunoblot versus crude brain membranes from adult mouse (MBM), rat (RBM) and human cerebral cortex [HBM(Cx)] and hippocampus [HBM(H)] probed with K36/15 (left) or N52A/42 (right) TC supe.
![Immunoblot versus crude brain membranes from adult mouse (MBM), rat (RBM) and human cerebral cortex [HBM(Cx)] and hippocampus [HBM(H)] probed with K36/15 (left) or N52A/42 (right) TC supe.](http://www.antibodiesinc.com/cdn/shop/products/validation-image-73-105-k36-15-wb-1_45d4f2d0-b0bc-43a6-8dc1-834ffee2fd56_1024x.jpg?v=1626902754)
Product Specific References for Applications and Species
- Immunocytochemistry: Human | Mouse | Rat
- Immunohistochemistry: Mouse | Rat
- Immunoprecipitation: Mouse
- Western Blot: Human | Mouse | Rat
| Immunocytochemistry: Human | ||
| PMID | Dilution | Publication |
| 28115470 | not listed | Lang, B., et al. 2017. Intracellular and non-neuronal targets of voltage-gated potassium channel complex antibodies. Journal of Neurology, Neurosurgery & Psychiatry, 88(4), pp.353-361.. Journal of Neurology, Neurosurgery & Psychiatry, 353-361. |
| 23774215 | not listed | Lallet-Daher, H., et al. 2013. Potassium channel KCNA1 modulates oncogene-induced senescence and transformation.. Cancer Research, 5253-5265. |
| 20663977 | 1:100 | Irani, S.R., et al. 2010. Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan''s syndrome and acquired neuromyotonia.. Brain, 2734-2748. |
| Immunocytochemistry: Mouse | ||
| PMID | Dilution | Publication |
| 28331203 | 1:100 | Rama, S., et al. 2017. The role of axonal Kv1 channels in CA3 pyramidal cell excitability. . Scientific reports, 1-12. |
| 21224222 | 1:2000 | Karcz, A., et al. 2011. Low‐voltage activated Kv1. 1 subunits are crucial for the processing of sound source location in the lateral superior olive in mice. . The Journal of physiology, 1143-1157. |
| Immunocytochemistry: Rat | ||
| PMID | Dilution | Publication |
| 33185190 | 1:100 | Sanders, S.S., et al. 2020. The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment. Elife, e56058. |
| 33168717 | not listed | Cho, I.H., et al. 2020. The potassium channel subunit Kvβ1 serves as a major control point for synaptic facilitation. PNAS:USA, 29937-29947. |
| 25447742 | 1:1000 | Hoppa, M.B., et al. 2014. Control and plasticity of the presynaptic action potential waveform at small CNS nerve terminals.. Neuron, 778-789. |
| 23836929 | 1:1000 | Sosanya, N.M., et al. 2013. Degradation of high affinity HuD targets releases Kv1.1 mRNA from miR-129 repression by mTORC1.. The Journal of Biology, 53-69. |
| 21357749 | not listed | Vacher, H., et al. 2011. Cdk-mediated phosphorylation of the Kvβ2 auxiliary subunit regulates Kv1 channel axonal targeting.. The Journal of Biology, 813-24. |
| 17185748 | not listed | Vacher, H., et al. 2007. Regulation of Kv1 channel trafficking by the mamba snake neurotoxin dendrotoxin K.. The FASEB Journal, 906-914. |
| Immunohistochemistry: Mouse | ||
| PMID | Dilution | Publication |
| 37408217 | 1:1000 | Martin, H, et al. 2023. Basket to Purkinje Cell Inhibitory Ephaptic Coupling Is Abolished in Episodic Ataxia Type 1. Cells, 1382. |
| 37283058 | 1:750 | Dustin, E, et al. 2023. Adult-onset Depletion of Sulfatide Leads to Axonal Degeneration with Relative Myelin Sparing. Glia, 2285-2303. |
| 36849716 | 1:100 | Hu, A., et al. 2023. Projection-Specific Heterogeneity of the Axon Initial Segment of Pyramidal Neurons in the Prelimbic Cortex. Neuroscience Bulletin, . |
| 36640913 | 1:500 | Otuyemi, B., et al. 2023. Domain and Cell Type-specific Immunolocalisation of Voltage-gated Potassium Channels in the Mouse Striatum. Journal of Chemical Neuroanatomy, 102233. |
| 36217300 | 1:200 | Nicholson, M., et al. 2022. Remodelling of Myelinated Axons and Oligodendrocyte Differentiation is Stimulated by Environmental Enrichment in the Young Adult Brain. The European Journal of Neuroscience, 6099-6114. |
| 35661858 | 1:500 | Nascimento, A.I., et al. 2022. Sensory neurons have an axon initial segment that initiates spontaneous activity in neuropathic pain. Brain, 1632-1640. |
| 31761670 | 1:200 | Klingseisen, A., et al. 2019. Oligodendrocyte neurofascin independently regulates both myelin targeting and sheath growth in the CNS. . Developmental cell, 730-744. |
| 31248728 | 1:250 | Zheng, Y., et al. 2019. Deep sequencing of somatosensory neurons reveals molecular determinants of intrinsic physiological properties. . Neuron, 598-616. |
| 29476105 | 1:200 | Nguyen, L.H., et al. 2018. mTOR-dependent alterations of Kv1.1 subunit expression in the neuronal subset-specific Pten knockout mouse model of cortical dysplasia with epilepsy. Scientific Reports, 3568. |
| 29476105 | 1:200 | Nguyen, L.H., et al. 2018. mTOR-dependent alterations of Kv1.1 subunit expression in the neuronal subset-specific Pten knockout mouse model of cortical dysplasia with epilepsy. Scientific Reports, 3568. |
| 28134616 | not listed | Amor, V., et al. 2017. The paranodal cytoskeleton clusters Na+ channels at nodes of Ranvier. . Elife, e21392. |
| 25290690 | not listed | Jones, K.S., et al. 2014. Neonatal NMDA receptor blockade disrupts spike timing and glutamatergic synapses in fast spiking interneurons in a NMDA receptor hypofunction model of schizophrenia.. PLoS One, e109303. |
| 24719087 | 1:100 | Desmazieres, A., et al. 2014. Differential stability of PNS and CNS nodal complexes when neuronal neurofascin is lost.. Journal of Neuroscience, 5083-5088. |
| 24200924 | 1:40 | Liu, Q., et al. 2014. Heterogeneous intrinsic excitability of murine spiral ganglion neurons is determined by Kv1 and HCN channels.. Neuroscience, 96-110. |
| 22612819 | not listed | Menegola, M., et al. 2012. The importance of immunohistochemical analyses in evaluating the phenotype of Kv channel knockout mice.. Epilepsia, 142-149. |
| 22473710 | 1:50 | Irani, S.R., et al. 2012. Morvan syndrome: clinical and serological observations in 29 cases.. Annals of Neurology, 241-255. |
| 21958379 | not listed | Duflocq, A., et al. 2011. Characterization of the axon initial segment (AIS) of motor neurons and identification of a para-AIS and a juxtapara-AIS, organized by protein 4.1B.. BMC Biology, 1-19. |
| 21220016 | not listed | Giacomini, C., et al. 2011. Both Schwann cell and axonal defects cause motor peripheral neuropathy in Ebf2-/- mice.. Neurobiology of Disease, 73-84. |
| 19118165 | 1:1000 | Lorincz, A., et al. 2008. Cell-type-dependent molecular composition of the axon initial segment. . Journal of Neuroscience, 14329-14340. |
| 19091962 | 1:1000 | Miller, M.N., et al. 2008. Region-specific spike-frequency acceleration in layer 5 pyramidal neurons mediated by Kv1 subunits.. Journal of Neuroscience, 13716-13726. |
| 18466749 | 10ug/ml | Goldberg, E.M., et al. 2008. K+ channels at the axon initial segment dampen near-threshold excitability of neocortical fast-spiking GABAergic interneurons.. Neuron, 387-400. |
| Immunohistochemistry: Rat | ||
| PMID | Dilution | Publication |
| 36050224 | 1:500 | Sharma, K., et al. 2022. Low-Voltage Activating K+ Channels in Cochlear Afferent Nerve Fiber Dendrites. Experimental Neurobiology, 243-259. |
| 34799447 | 1:100 | Zbili, M., et al. 2021. Homeostatic regulation of axonal Kv1. 1 channels accounts for both synaptic and intrinsic modifications in the hippocampal CA3 circuit. PNAS:USA, . |
| 32345673 | 1:300 | Housley, S.N., et al. 2020. Cancer exacerbates chemotherapy-induced sensory neuropathy. . Cancer research, 2940-2955. |
| 28331203 | 1:50 | Rama, S., et al. 2017. The role of axonal Kv1 channels in CA3 pyramidal cell excitability. . Scientific reports, 1-12. |
| 24723263 | 1:100 | Dufour, M.A., et al. 2014. Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development.. Journal of Neuroscience Research, 981-999. |
| 24606584 | 1:250 | Kirizs, T., et al. 2014. Distinct axo-somato-dendritic distributions of three potassium channels in CA1 hippocampal pyramidal cells.. European Journal of Neuroscience, 1711-1783. |
| 23439123 | 1:50 | Campanac, E., et al. 2013. Enhanced intrinsic excitability in basket cells maintains excitatory-inhibitory balance in hippocampal circuits.. Neuron, 712-722. |
| 19118165 | 1:1000 | Lorincz, A., et al. 2008. Cell-type-dependent molecular composition of the axon initial segment. . Journal of Neuroscience, 14329-14340. |
| Immunoprecipitation: Mouse | ||
| PMID | Dilution | Publication |
| 22067099 | 15ug/ml | Bildl, W., et al. 2012. Extending the dynamic range of label-free mass spectrometric quantification of affinity purifications.. Molecular & Cellular Proteomics, . |
| 22158511 | 10ul | Li, K.K., et al. 2011. Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy.. Nature Neuroscience, 267-273. |
| Western Blot: Human | ||
| PMID | Dilution | Publication |
| 23774215 | not listed | Lallet-Daher, H., et al. 2013. Potassium channel KCNA1 modulates oncogene-induced senescence and transformation.. Cancer Research, 5253-5265. |
| 23734863 | not listed | Zhao, J., et al. 2013. Spinocerebellar ataxia-13 Kv3.3 potassium channels: arginine-to-histidine mutations affect both functional and protein expression on the cell surface.. Biochemical Journal, 259-265. |
| 22609616 | 1:1000 | Zhu, J., et al. 2012. Characterization of the Kv1.1 I262T and S342I mutations associated with episodic ataxia 1 with distinct phenotypes.. Archives of Biochemistry and Biophysics, 99-105. |
| Western Blot: Mouse | ||
| PMID | Dilution | Publication |
| 25707359 | not listed | Chen, N., et al. 2015. Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes.. Biochimica et Biophysica Acta, 827-833. |
| 23945775 | not listed | Kyle, B.D., et al. 2013. The large conductance, calcium-activated K+ (BK) channel is regulated by cysteine string protein.. Scientific Reports, 2447. |
| 22449950 | not listed | Bangratz, M., et al. 2012. A mouse model of Schwartz-Jampel syndrome reveals myelinating Schwann cell dysfunction with persistent axonal depolarization in vitro and distal peripheral nerve hyperexcitability when perlecan is lacking.. The American Journal of Pathology, 2040-2055. |
| 22067099 | 1:10,000 | Bildl, W., et al. 2012. Extending the dynamic range of label-free mass spectrometric quantification of affinity purifications.. Molecular & Cellular Proteomics, . |
| Western Blot: Rat | ||
| PMID | Dilution | Publication |
| 33185190 | 1:500 | Sanders, S.S., et al. 2020. The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment. Elife, e56058. |
| 32437528 | not listed | Ramberger, M., et al. 2020. Distinctive binding properties of human monoclonal LGI1 autoantibodies determine pathogenic mechanisms. Brain, 1731-1745. |
| 28673977 | not listed | Seagar, M., et al. 2017. LGI1 tunes intrinsic excitability by regulating the density of axonal Kv1 channels. Proceedings of the National Academy of Sciences, 114(29), pp.7719-7724.. Proceedings of the National Academy of Sciences, 7719-7724. |
| 25270294 | 1 : 500 | Sosanya, N.M., et al. 2015. Rapamycin reveals an mTOR-independent repression of Kv1.1 expression during epileptogenesis.. Neurobiology of Disease, 96-105. |
| 17185748 | not listed | Vacher, H., et al. 2007. Regulation of Kv1 channel trafficking by the mamba snake neurotoxin dendrotoxin K.. The FASEB Journal, 906-914. |