Immunoblot versus crude brain membranes from adult mouse (MBM), rat (RBM) and human cerebral cortex [HBM(Cx)] and hippocampus [HBM(H)] probed with K36/15 (left) or N52A/42 (right) TC supe.
Anti-Kv1.1 K+ Channel (External) Antibody
Kv1.1 K+ channel (external)
Potassium Channel Kv1.1or Kcna1 is a member of the Shaker potassium channel family. Kv1.1 is expressed in the brain, CNS and in the kidney. Potassium channels form homotetrameric and heterotetrameric channels in the membrane with various other related proteins, including KCNA2, KCNA4, KCNA5, KCNA6, KCNA7. Kv1.1 is involved with the regulation of cellular functions and the control of neuronal excitability. Mutations in Kv1.1 are associated with Episodic ataxia type 1 and epilepsy.
ICC, IHC, WB
56 kDa (could be 65-85 kDa depending on glycosylation)
Synthetic peptide amino acids 191-208 (ELKDDKDFTGTIHRIDNTC, extracellular domain) of rat Kv1.1 (also known as potassium voltagegated channel subfamily A member 1, IA, RBKI, RCK1, accession number P10499); Mouse: 100% identity (18/18 amino acids identical); Human: 94% identity (17/18 amino acids identical)
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.