Tissue and transfected cell immunoblot: extracts of rat brain membrane (RBM) and COS cells transiently transfected with Flag-tagged Kirrel3-short, Kirrel3-long, untagged Kirrel2, Kirrel1 or Kv2.1 plasmid and probed with N321C/49 (left) and N52A/42 (right) TC supe.
Anti-Kirrel3 Short And Long Antibody
Membrane protein KIRRE
Kirre Like Nephrin Family Adhesion Molecule 3 is encoded by the gene KIRREL3. KIRREL3 is a member of the immunoglobulin superfamily, nephrin-like protein family. KIRREL3 is a synaptic cell adhesion molecule with multiple extracellular immunoglobulin-like domains and a cytoplasmic PDZ domain-binding motif. KIRREL3 is expressed in brain, bone marrow, and stromal cells. Diseases associated with KIRREL3 include Autosomal Dominant Non-Syndromic Intellectual Disability and Autosomal Dominant Non-Syndromic Intellectual Disability 4.
85-105 kDa (multiple isoforms)
Fusion protein amino acids 46-524 (extracellular N-terminus) of rat Kirrel3 (also known as Kin of irregular chiasm-like protein 3, Kin of IRRE-like protein 3, Nephrin-like protein 2, NEPH2 and Kiaa1867, accession number Q09GS6)
Mouse: 97% identity (479/491 amino acids identical); Human: 95% identity (470/491 amino acids identical); 100% identity between short and long isoforms; ~50% identity with Kirrel1 and Kirrel2
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Reacts with Kirrel3 short and long isoforms
Does not cross-react with Kirrel1 and Kirrel2
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.