Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and COS cells transiently transfected with HA-tagged Kir2.2 or untagged Kv2.1 plasmids and probed with N124B/38 TC supe.
Anti-Kir2.2 K+ Channel Antibody
Kir2.2 K+ channel
ATP-sensitive inward rectifier potassium channel 12or Kir2.2 is encoded by the gene KCNJ12. Kir2.2 is a member of the inward rectifier potassium ion channel family and plays a role controlling the resting membrane potential in muscle cells and neurons. Kir2.2 is an integral membrane protein that is expressed in heart, brain and in aortic endothelial cells. In brain, Kir2.2 is expressed throughout the forebrain and cerebellum. Diseases associated with KCNJ12 include Smith-Magenis Syndrome and Leber Congenital Amaurosis 16.
Synthetic peptide amino acids 390-410 (cytoplasmic C-terminus) of rat Kir2.2 (also known as ATP-sensitive inward rectifier potassium channel 12 or subfamily J member 12, Kcnj12, Kcnjn1 and Irk2, accession number P52188); Mouse: 85% identity (18/21 amino acids identical); Human: 57% identity (15/26 amino acids identical)
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
No cross-reactivity against Kir2.1 or Kir2.3
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.