Immunoblot versus (E) membrane proteins from wild- type (wt), Slo3-eGFP and Slo3 knockout (Slo3-/-) mouse testes and (F) immunoprecipitation products from total testes proteins pulled down with N2/16 probed with N2/16. Data courtesy of Christopher Lingle (Washington University) and reproduced with permission from the Proceedings of the National Academy of Sciences of the United States of America (2011 Zeng et al., PMID 21427226).
Potassium calcium-activated channel subfamily U member 1 is encoded by the gene KCNU1. KCNU1 is a member of the potassium channel family, calcium-activated (TC 1.A.1.3) subfamily, KCa5.1/KCNU1 sub-subfamily. KCNU1 is a testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates transport of K+. KCNU1 is expressed in the testis. Diseases associated with KCNU1 include Leukodystrophy, Hypomyelinating, 3 and Coffin-Siris Syndrome 1.
Kcnu1 Kcnma3 Ksper Slo3
Fusion protein amino acids 1052-1121 of mouse Slo3 (also known as Potassium channel subfamily U member 1, Pore-forming subunit of the sperm-specific alkalization activated K(+) current, Calcium-activated potassium channel subunit alpha-3, Calcium-activated potassium channel, subfamily M subunit alpha-3, Slowpoke homolog 3, Kcnu1, KCa5, Kcnma3, Kcnmc1 and Ksper, accession number O54982)
50% identity with human and rat KCNU1/Slo3
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
24 months from opening
Potassium channel subfamily U member 1 (Calcium-activated potassium channel subunit alpha-3) (Calcium-activated potassium channel, subfamily M subunit alpha-3) (Pore-forming subunit of the sperm-specific alkalization activated K(+) current) (KSper) (Slowpoke homolog 3) (mSlo3) (pH-sensitive maxi potassium channel)