Anti-IKK gamma (N-terminal) Antibody

Name: Anti-IKK gamma (N-terminal) Antibody
Brand: PhosphoSolutions
SKU: 24161
Price: 456.0 USD
Availability: InStock

Our IKK gamma rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human IKK gamma and is antigen affinity purified. It is great for use in WB.

Western Blot of Interleukin 1 stimulated 293 cell lysate showing specific immunolabeling of IKK-gamma.

Click on image to zoom

Species Reactivity

Human

Applications

ELISA, WB

Host Species

Rabbit

Go to Full Product Details

Data Sheet

SKU: 24161

Title: 100 µL

Variant

Price:

$456.00

Quantity:

Ships: 1-2 business days

Product Details

Target

IKK gamma

Scientific Background

Pro-inflammatory cytokines activate the transcription factor NF-kappaB by stimulating the activity of a protein kinase that phosphorylates IkappaB, an inhibitor of NF-kappaB, at sites that trigger its ubiquitination and degradation. A large, cytokine-responsive IkappaB kinase (IKK) complex contains 2 subunits, IKK-alpha and IKK-beta, which are protein kinases whose function is needed for NF-kappaB activation by pro-inflammatory stimuli. IKK is composed of similar amounts of IKK-alpha, IKK-beta, which are differentially processed forms of a third subunit, IKK-gamma. IKK-gamma interacts preferentially with IKK-beta and is required for the activation of the IKK complex.

Format

Antigen Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB

Host Species

Rabbit

Gene Name

IKBKG

Immunogen

Synthetic peptide corresponding to amino acids from the N-terminal region of human IKK gamma protein

Immunogen Species

Human

Species Reactivity

Human

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Buffer

PBS + 0.02% NaN3

Dilution Ranges

WB: 1:500-1:1000
WB Brain: 1:500-1:1000

Specificity

Reacts with the N-terminal region of human IKK gamma protein. Recognizes both human isoforms.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Synonyms

AMCBX1; IKBKG; FIP3; Fip3p; IKK-gamma; IKKAP1; IKKG; IMD33; IP1; IP2; IPD2; NEMO; ZC2HC9; NF-kappa-B essential modulator; I-kappa-B kinase subunit gamma; NF-kappa-B essential modifier; ikB kinase subunit gamma; ikB kinase-associated protein 1; incontinentia pigmenti; IkB kinase associated protein 1; Inhibitor of kappa light polypeptide gene enhancer in B cells; kinase gamma; NF kappa B essential modifier

UniProt ID

Q9Y6K9
UniProt Summary: Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin plays a key role in IKK activation by multiple signaling receptor pathways. Can recognize and bind both 'Lys-63'-linked and linear polyubiquitin upon cell stimulation, with a much higher affinity for linear polyubiquitin. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.

NCBI Gene ID

8517

Shipping

Blue Ice

Recover password

Create my account

Anti-IKK gamma (N-terminal) Antibody

SKU: 24161

Product Details

Bulk Order Anti-IKK gamma (N-terminal) Antibody

Related Products

Recently Viewed