Anti-Iduna/RNF146 Antibody (N201/35)

Name: Anti-Iduna/RNF146 Antibody
Brand: NeuroMab
SKU: 75-233
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet

2 Citations

Available Conjugates

490

550

594

650

Product Type

Primary Antibody

Species Reactivity

Mouse, Rat

Clone

N201/35

Applications

ICC, WB

Host Species

Mouse

Format

Purified by Protein A chromatography

Gene Name

Rnf146

Molecular Weight

40 kDa

Go to Full Product Details

Adult rat brain membrane immunoblot.

Volume: 100 µL

Variant

Price:

$308

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Product Details

Target

Iduna/RNF146

Target Description

E3 ubiquitin-protein ligase RNF146, RING finger protein 146 or Iduna is encoded by the gene RNF146. Iduna is a ubiquitin protein ligase that is involved in ubiquitination and degradation. It is thought to be involved with diverse processes including DNA repair, activation of the Wnt signaling pathway, protection from DNA damage induced cell death. Iduna is found in many tissues including brain, heart, spleen, kidney and liver.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N201/35

Isotype

IgG1

Applications

ICC, WB

Host Species

Mouse

Gene Name

Rnf146

Molecular Weight

40 kDa

Antigen

Fusion protein amino acids 1-359 (full-length) of mouse Iduna (accession number Q9CZW6) produced recombinantly in E. Coli

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_10672248

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

E3 ubiquitin-protein ligase RNF146 (EC 2.3.2.27) (Iduna) (RING finger protein 146) (RING-type E3 ubiquitin transferase RNF146)

UniProt Details

UniProt (Human): Q9NTX7
UniProt (Immunogen Species): Q9CZW6

Xu H, Luo P, Zhao Y, Zhao M, Yang Y, Chen T, Huo K, Han H, Fei Z. (2013), 'Iduna protects HT22 cells from hydrogen peroxide-induced oxidative stress through interfering poly(ADP-ribose) polymerase-1-induced cell death (parthanatos)..' Cellular Signalling. 10.1016/j.cellsig.2013.01.006.
Kang HC, Lee YI, Shin JH, Andrabi SA, Chi Z, Gagné JP, Lee Y, Ko HS, Lee BD, Poirier GG, Dawson VL, Dawson TM. (2011), 'Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage..' Proceedings of the National Academy of Science of the United States of America. 10.1073/pnas.1108799108.

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Anti-Iduna/RNF146 Antibody (N201/35)

Available Conjugates

Anti-Iduna/RNF146 Antibody
SKU: 75-233

Bulk Order Anti-Iduna/RNF146 Antibody

Product Details

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Anti-Iduna/RNF146 Antibody (N201/35)

Available Conjugates

Anti-Iduna/RNF146 Antibody SKU: 75-233

Bulk Order Anti-Iduna/RNF146 Antibody

Product Details

Anti-Iduna/RNF146 Antibody
SKU: 75-233