Anti-HCN4 Antibody (N114/10)

Name: Anti-HCN4 Antibody
Brand: NeuroMab
SKU: 75-150
Price: 285.0 USD
Availability: InStock

from NeuroMab Datasheet

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Clonality

Monoclonal

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

HCN4

Molecular Weight

130 kDa

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Adult rat retina membrane immunoblot (left) and immunofluorescence (right). Green = N114/10 staining of the inner nuclear, inner plexiform, ganglion cell and optic fiber layers (INL, IPL, GCL, and OFL), where layers are viewed by differential interference contrast microscopy. Data courtesy of Gloria Partida, Tyler Stradleigh, and Andrew Ishida (UCDavis).

Adult rat thalamus immunohistochemistry.

Adult rat retina membrane immunoblot (left) and immunofluorescence (right). Green = N114/10 staining of the inner nuclear, inner plexiform, ganglion cell and optic fiber layers (INL, IPL, GCL, and OFL), where layers are viewed by differential interference contrast microscopy. Data courtesy of Gloria Partida, Tyler Stradleigh, and Andrew Ishida (UCDavis).

Product Details

Target

HCN4

Target Description

HCN4 is a member of the hyperpolarization-activated cyclic nucleotide gated channel family, also known as pacemaker channels. This family has a role in rhythmic activity of the heart and firing neurons. HCN channels are made up of four subunits, HCN1-4 and can be formed in multiple combinations. HCN4 is found in the cell membrane as a multi pass membrane protein in the sino-atrial node of the heart. This protein is highly expressed in neurons in the thalamus and other brain regions and testis. Mutations in HCN4 have been found in several types of sinus bradycardia.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N114/10

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

HCN4

Molecular Weight

130 kDa

Antigen

Fusion protein amino acids 1019-1108 (cytoplasmic Cterminus) of rat HCN4(also known as potassium/sodium hyperpolarization-activated cyclic nucleotidegated channel 4, brain cyclic nucleotide-gated channel 3 and BCNG-3, accession number Q9JKA7); Mouse: 100% identity (90/90 amino acids identical); Human: 100% identity (90/90 amino acids identical); Less than 50% identity with HCN1, HCN2 and HCN3

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2248534

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

No cross-reactivity against other HCN’s

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

UniProt Details

UniProt (Human): Q9Y3Q4
UniProt (Immunogen Species): Q9Y3Q4

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Anti-HCN4 Antibody (N114/10)

Anti-HCN4 Antibody
SKU: 75-150

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