Anti-Glial cell line-derived neurotrophic factor (GDNF) Antibody

Name: Anti-Glial cell line-derived neurotrophic factor (GDNF) Antibody
Brand: Biosensis
SKU: C-1518-500
Price: 337.0 USD
Availability: InStock

Our Anti-Glial cell line-derived neurotrophic factor (GDNF) chicken polyclonal primary antibody detects human, mouse, and rat Glial cell line-derived neurotrophic factor (GDNF), and is affinity-purified. It is validated for use in ELISA, ICC, IHC-Frozen, WB.

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Chicken

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Data Sheet

SKU: C-1518-500

Volume/Size: 500 µL

Variant

Price:

$337.00

Quantity:

Product Details

Target

Glial cell line-derived neurotrophic factor (GDNF)

Scientific Background

GDNF is a glycosylated, disulfide-bonded homodimer molecule. It was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is about 100 times more efficient survival factor for spinal motor neurons than the neurotrophins. FUNCTION: Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. SUBUNIT: Homodimer; disulfide-linked. SUBCELLULAR LOCATION: Secreted protein. ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. DISEASE: Defects in GDNF may be a cause of Hirschsprung disease (HSCR). In association with mutations of RET gene, defects in GDNF may be involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. DISEASE: Defects in GDNF are a cause of congenital central hypoventilation syndrome (CCHS); also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.

Format

Affinity-purified

Clonality

Polyclonal

Isotype

IgY

Applications

ELISA, ICC, IHC, WB

Host Species

Chicken

Immunogen

Mixture of two human GDNF peptides (101-118 and 199-211 aa). Both peptides are highly conserved in human and mouse.

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Storage

Short term storage at 2-8°C for one week. At -20°C as an undiluted liquid for up to 12 months.

Physical State

Liquid

Buffer

PBS with 0.02% sodium azide.

Dilution Ranges

WB: 1:500-1:2000
IHC: 1:50-1:100

Conjugate

Unconjugated

Specificity

Human GDNF, cross reactivity to mouse, rat.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

Glial cell line-derived neurotrophic factor; Astrocyte-derived trophic factor; ATF; GDNF;

UniProt ID

P39905

Shipping

2-8°C (on cold packs)

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Anti-Glial cell line-derived neurotrophic factor (GDNF) Antibody

SKU: C-1518-500

Product Details

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