Anti-GABARAP Antibody

Name: Anti-GABARAP Antibody
Brand: PhosphoSolutions
SKU: 24145
Price: 456.0 USD
Availability: InStock

Our GABARAP rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human, mouse, and rat GABARAP and is antigen affinity purified. It is great for use in WB.

Western Blot of rat brain lysate showing specific immunolabeling of the GABARAP.

Click on image to zoom

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, WB

Host Species

Rabbit

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Data Sheet

SKU: 24145

Title: 100 µL

Variant

Price:

$456.00

Quantity:

Ships: 1-2 business days

Product Details

Target

GABARAP

Scientific Background

GABAa Receptor Associated Protein (GABARAP) interacts with the gamma2 subunit of GABAa receptors.

Format

Antigen Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB

Host Species

Rabbit

Gene Name

GABARAP

Immunogen

Synthetic peptide corresponding to amino acids from the N-terminal region of human GABARAP protein

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Buffer

PBS + 0.02% NaN3

Dilution Ranges

WB: 1:500-1:1000
WB Brain: 1:500-1:1000

Specificity

Reacts with the N-terminal region of human, mouse and rat GABARAP protein

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Synonyms

ATG8A; GABAa Receptor Associated Protein; MM46; GABA(A receptor-associated protein

UniProt ID

O95166
UniProt Summary: Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in autophagy: while LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover. Also required for the local activation of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex, regulating ubiquitination and degradation of TIAM1, a guanyl-nucleotide exchange factor (GEF) that activates RAC1 and downstream signal transduction. Thereby, regulates different biological processes including the organization of the cytoskeleton, cell migration and proliferation. Involved in apoptosis.

NCBI Gene ID

11337

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Anti-GABARAP Antibody

SKU: 24145

Product Details

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