Anti-GABA-A-R-Gamma2L Antibody (N452/69)

Name: Anti-GABA-A-R-Gamma2L Antibody
Brand: NeuroMab
SKU: 75-442
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

N452/69

Applications

ICC, IHC, WB

Host Species

Mouse

Format

Purified

Gene Name

GABRG2

Molecular Weight

45 kDa

Go to Full Product Details

Adult rat brain membrane immunoblot.

Volume: 100 µL

Variant

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$308

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Product Details

Target

Gamma-aminobutyric acid receptor subunit gamma-2 (GABA(A) receptor subunit gamma-2)

Target Description

Gamma-aminobutyric acid receptor subunit gamma-2, or GABA AR gamma2 is encoded by the gene GABRG2. GABA A receptors are members of the Cys-loop family of ligand-gated ion channels. GABA AR gamma2 is a subunit of the pentameric GABA receptors where GABA is the major inhibitory neurotransmitter in the vertebrate brain and mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. GABA AR gamma2 has been found expressed in stomach and bladder. In brain, GABA AR gamma2 is expressed at the cell junction, synapse, postsynaptic cell membrane and cytoplasmic vesicle membrane. Mutations in this gene have been associated with epilepsy and febrile seizures. Note that GABA AR ?2 subunit has two forms, designated “short” (?2S) and “long” (?2L) that differ only in eight amino acids inserted into the large intracellular loop of the subunit (Whiting et al., 1990).

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N452/69

Isotype

IgG2a

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

GABRG2

Molecular Weight

45 kDa

Antigen

Fusion protein amino acids 360-445 (cytoplasmic C-terminus) of human GABA-A-R-Gamma2L (also known as Gamma-aminobutyric acid receptor subunit gamma-2 and GABRG2, accession number P18507-2); Mouse: 100% identity (86/86 amino acids identical); Rat: 100% identity (86/86 amino acids identical)90% identity with GABA-A-R-Gamma2S (amino acids 377-384, LLRMFSFK, unique to Gamma2L); 50% identity with GABA-A-R-Gamma1 and GABA-A-R-Gamma3

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2617122

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Does not cross-react with GABA-A-R-Gamma2S, GABA-A-R-Gamma1 or GABAA-A-R-Gamma3

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Gamma-aminobutyric acid receptor subunit gamma-2 (GABA(A) receptor subunit gamma-2)

UniProt Details

UniProt (Human): P18507
UniProt (Immunogen Species): P18507-2

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Anti-GABA-A-R-Gamma2L Antibody (N452/69)

Anti-GABA-A-R-Gamma2L Antibody
SKU: 75-442

Bulk Order Anti-GABA-A-R-Gamma2L Antibody

Product Details

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Anti-GABA-A-R-Gamma2L Antibody (N452/69)

Anti-GABA-A-R-Gamma2L Antibody SKU: 75-442

Bulk Order Anti-GABA-A-R-Gamma2L Antibody

Product Details

Anti-GABA-A-R-Gamma2L Antibody
SKU: 75-442