Anti-GABA-A-R, Delta Antibody (N151/3)

Name: Anti-GABA-A-R, Delta Antibody
Brand: NeuroMab
SKU: 75-171
Price: 329.0 USD
Availability: InStock

Our mouse GABA(A)R, Delta monoclonal antibody from NeuroMab is produced in-house from clone N151/3. It detects human, mouse, and rat GABA(A)R, Delta and is purified by Protein A chromatography. Works in WB, ICC, ELISA.

Cerebellar lysate immunoblot probed with N151/3 (3 mg/mL).

Cultured rat hippocampal neuron surface (S, left) and total (T, right) protein immunofluorescence staining (green) with N151/3 (2 mg/mL).

Hippocampus immunohistochemistry with N151/3 (5 mg/mL).

Cerebellar lysate immunoblot probed with N151/3 (3 mg/mL).

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Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-171

Volume: 100 µL

Variant

Price:

$329.00

Quantity:

Ships: 1-2 business days

Product Details

Target

GABA(A)R, Delta

Scientific Background

Gamma-aminobutyric acid receptor subunit delta or Delta GABA-A receptor is encoded by the gene GABRD. GABAA receptors are members of the Cys-loop family of ligand-gated ion channels. GABA AR delta is a subunit of the pentameric GABA receptors where GABA is the major inhibitory neurotransmitter in the vertebrate brain and mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. GABA AR delta is highly expressed in brain at the cell junction, synapse, postsynaptic cell membrane and cytoplasmic vesicle membrane. Mutations in this gene have been associated with susceptibility to generalized epilepsy with febrile seizures.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N151/3

Isotype

IgG2a

Applications

ELISA, ICC, WB

Host Species

Mouse

Gene Name

Gabrd

Molecular Weight

55 kDa

Immunogen

Synthetic peptide amino acids 15-34 (CTQPHHGARAMNDIGDYVGS, extracellular N-terminus) of rat GABA-A-R-Delta (accession number P18506)

Immunogen Species

Rat

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2107254

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.99

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

GABA(A receptor subunit delta; Gamma-aminobutyric acid receptor subunit delta; Gabrd; GABA(A receptor subunit delta; Gamma aminobutyric acid GABA A receptor delta; Gamma aminobutyric acid receptor delta subunit precursor GABA A receptor; Gamma-aminobutyric acid receptor subunit delta; GBRD_HUMAN; MGC45284

UniProt ID

P18506
UniProt Summary: Delta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. GABAARs containing delta/GABRD subunits are predominantly expressed and located in extrasynaptic or perisynaptic positions on hippocampus and cerebellar granule cells, and contribute to the tonic GABAergic inhibition. GABAAR containing alpha-4-beta-3-delta subunits can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness.

NCBI Gene ID

29689

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Anti-GABA-A-R, Delta Antibody (N151/3)

SKU: 75-171

Product Details

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