Anti-GABA(A)R, Delta Antibody (N151/3)

Name: Anti-GABA(A)R, Delta Antibody
Brand: NeuroMab
SKU: 75-171
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet

3 Citations

Product Type

Primary Antibody

Species Reactivity

Mouse, Rat

Clone

N151/3

Applications

ICC, WB

Host Species

Mouse

Format

Purified

Gene Name

Gabrd

Molecular Weight

55 kDa

Go to Full Product Details

Cerebellar lysate immunoblot probed with N151/3 (3 mg/mL).

Cultured rat hippocampal neuron surface (S, left) and total (T, right) protein immunofluorescence staining (green) with N151/3 (2 mg/mL).

Hippocampus immunohistochemistry with N151/3 (5 mg/mL).

Cerebellar lysate immunoblot probed with N151/3 (3 mg/mL).

Volume: 100 µL

Variant

Price:

$308

Quantity:

Bulk Order Anti-GABA(A)R, Delta Antibody

Product Details

Target

GABA(A)R, Delta

Target Description

Gamma-aminobutyric acid receptor subunit delta or Delta GABA-A receptor is encoded by the gene GABRD. GABAA receptors are members of the Cys-loop family of ligand-gated ion channels. GABA AR delta is a subunit of the pentameric GABA receptors where GABA is the major inhibitory neurotransmitter in the vertebrate brain and mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. GABA AR delta is highly expressed in brain at the cell junction, synapse, postsynaptic cell membrane and cytoplasmic vesicle membrane. Mutations in this gene have been associated with susceptibility to generalized epilepsy with febrile seizures.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N151/3

Isotype

IgG2a

Applications

ICC, WB

Host Species

Mouse

Gene Name

Gabrd

Molecular Weight

55 kDa

Antigen

Synthetic peptide amino acids 15-34 (CTQPHHGARAMNDIGDYVGS, extracellular N-terminus) of rat GABA-A-R-Delta(also known as gamma-aminobutyric acid receptor subunit delta, accession number P18506); Mouse: 100% identity (20/20 amino acids identical); Human: 75% identity (15/20 amino acids identical)

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2107254

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Gamma-aminobutyric acid receptor subunit delta (GABA(A) receptor subunit delta)

UniProt Details

UniProt (Human): O14764
UniProt (Immunogen Species): P18506

Joshi S, Keith KJ, Ilyas A, Kapur J. (2013), 'GABAA receptor membrane insertion rates are specified by their subunit composition..' Molecular and Cellular Neuroscience. 10.1016/j.mcn.2013.05.003.
Joshi S, Kapur J. (2013), 'N-methyl-D-aspartic acid receptor activation downregulates expression of δ subunit-containing GABAA receptors in cultured hippocampal neurons..' Molecular Pharmacology. 10.1016/j.eplepsyres.2011.02.008.
Kharlamov EA, Lepsveridze E, Meparishvili M, Solomonia RO, Lu B, Miller ER, Kelly KM, Mtchedlishvili Z. (2011), 'Alterations of GABA(A) and glutamate receptor subunits and heat shock protein in rat hippocampus following traumatic brain injury and in posttraumatic epilepsy..' Epilepsy Research. .

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Anti-GABA(A)R, Delta Antibody (N151/3)

Anti-GABA(A)R, Delta Antibody
SKU: 75-171

Bulk Order Anti-GABA(A)R, Delta Antibody

Product Details

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Anti-GABA(A)R, Delta Antibody (N151/3)

Anti-GABA(A)R, Delta Antibody SKU: 75-171

Bulk Order Anti-GABA(A)R, Delta Antibody

Product Details

Anti-GABA(A)R, Delta Antibody
SKU: 75-171