Anti-c-FOS Antibody (N486/32)

Name: Anti-c-FOS Antibody
Brand: NeuroMab
SKU: 75-506
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet

1 Citation

Available Conjugates

490

550

594

650

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

N486/32

Applications

ICC, IHC, WB

Host Species

Mouse

Format

Purified by Protein A chromatography

Gene Name

FOS, G0S7

Molecular Weight

70 kDa

Go to Full Product Details

Rat spinal cord sections labeling cFOS (green, Cat 75-506) to confirm excitation of aerents by DREAD. Two “experimental” rats (A,B) received excitatory DREADDS injections into DRGs (AAV2-hSyn-hM3Dq-mCherry). Three weeks later rats were injected with CNO (4 mg/kg), rested 30 minutes followed by running one hour on traeadmill, then sacrificed. Two control rats, (C) had DRGs injected with mCherry sham (AAV2-hSyn-mCherry), or (D) no DRG injections. Image from publication CC-BY-4.0. PMID: 36090254

Anti-c-FOS Antibody

Volume: 100 µL

Variant

Price:

$308

Quantity:

Bulk Order Anti-c-FOS Antibody

Product Details

Target

c-FOS

Target Description

C-fos belongs the Fos family. Other members include FosB, Fra-1, Fra-2. c-fos binds to JUN/AP1 transcription factor. C-Fos is expressed in placental tissue, fetal liver, developing bone, developing central nervous system, and adult bone marrow. It is expressed in the nucleus and in the endoplasmic reticulum. c-Fos is has a role in signal transduction, cell proliferation, differentiation, and apoptosis. C-Fos is overexpressed in many cancers.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N486/32

Isotype

IgG2a

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

FOS, G0S7

Molecular Weight

70 kDa

Antigen

Fusion protein amino acids 1-377 (full-length) of human FOS (accession number P01100) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2927659

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when tested by Western Blot.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Proto-oncogene c-Fos, Cellular oncogene fos, G0/G1 switch regulatory protein 7

UniProt Details

UniProt (Human): P01100
UniProt (Immunogen Species): P01100

Product Specific References for Applications and Species

Immunohistochemistry: Rat

Immunohistochemistry: Rat
PMID	Dilution	Publication
36090254	not listed	Eisdorfer, J.T., et al. 2022. Chemogenetic modulation of sensory afferents induces locomotor changes and plasticity after spinal cord injury. Frontiers in Molecular Neuroscience, 872634.

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Anti-c-FOS Antibody (N486/32)

Available Conjugates

Anti-c-FOS Antibody
SKU: 75-506

Bulk Order Anti-c-FOS Antibody

Product Details

Product Specific References for Applications and Species

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Anti-c-FOS Antibody (N486/32)

Available Conjugates

Anti-c-FOS Antibody SKU: 75-506

Bulk Order Anti-c-FOS Antibody

Product Details

Product Specific References for Applications and Species

Anti-c-FOS Antibody
SKU: 75-506